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It covers the mathematical details of model creation and evaluation, including discrimination, calibration, and predictive performance with censored data and competing risks, with R-code and illustrative examples. 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The book focuses on the individualized probability of a medical event occurring within a specific time horizon. Gerds and Kattan provide a clear and pedagogical explanation of the mathematical details involved in creating and evaluating statistical prediction models, without resorting to mathematical notation. This book is an invaluable resource for anyone who is unsure about whether a Cox regression model outperforms a random survival forest.\u003cbr\u003e\u003cbr\u003eKey Features:\u003cbr\u003e\u003cbr\u003e1. Comprehensive Coverage: The book covers all the essential aspects of statistical prediction models, including discrimination, calibration, predictive performance with censored data and competing risks, R-code and illustrative examples, interpretation of prediction performance via benchmarks, and comparison and combination of rival modeling strategies via cross-validation.\u003cbr\u003e\u003cbr\u003e2. 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It offers an insight into the implications of research on aging genetics, the Demographic Theory of Senescence, whereby aging has been affirmatively selected because it levels the death rate over time, helping stabilize population dynamics and prevent extinctions.\u003c\/p\u003e\u003cp\u003e                            \u003cstrong\u003eWeight\u003c\/strong\u003e: 449g                            \u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 234 x 156 (mm)                            \u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9780367782733                                                      \u003c\/p\u003e","brand":"Joshua Mitteldorf","offers":[{"title":"Paperback \/ softback","offer_id":44103833092346,"sku":"9780367782733","price":48.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/75c9ad4f814ca575d33411a84042f0ff.jpg?v=1620649368"},{"product_id":"molecular-cell-biology-of-the-growth-and-differentiation-of-plant-cells","title":"Molecular Cell Biology of the Growth and Differentiation of Plant Cells","description":"\u003cp\u003e\u003c\/p\u003e\u003cblockquote\u003eMolecular Cell Biology of the Growth and Differentiation of Plant Cells explores cell division, cell enlargement, and differentiation, providing a foundation for improving plant growth and developing special plant products. It covers the dynamics of cells and organelles using molecular genetics and visualization techniques, with chapters on the cell cycle, cell enlargement, and cell differentiation. The book is suitable for plant cell biologists, molecular biologists, plant physiologists, biochemists, developmental biologists, and those interested in plant growth and development. \u003c\/blockquote\u003e\u003cp\u003e                                                            \u003cstrong\u003eFormat\u003c\/strong\u003e: Paperback \/ softback\u003cbr\u003e                              \u003cstrong\u003eLength\u003c\/strong\u003e: 396 pages\u003cbr\u003e                              \u003cstrong\u003ePublication date\u003c\/strong\u003e: 31 March 2021\u003cbr\u003e                              \u003cstrong\u003ePublisher\u003c\/strong\u003e: Taylor \u0026amp; Francis Ltd\u003cbr\u003e                          \u003c\/p\u003e \u003cp\u003e\u003cbr\u003eMolecular Cell Biology of the Growth and Differentiation of Plant Cells is a comprehensive exploration of the cellular processes that underlie plant growth and development. It covers cell division, cell enlargement, and differentiation, which are essential for the formation and growth of plants. By understanding these developmental processes, researchers can improve plant growth, develop specialized plant products, and contribute to our understanding of biology. The book delves into the dynamics of cells and cellular organelles, facilitated by advances in molecular genetics and the visualization of organelles using molecular probes. It presents a current and conceptual view of these processes, organized into three main chapters: cell cycle, cell enlargement, and cell differentiation. The book provides a comprehensive and up-to-date knowledge base, covering both established concepts and open questions. It serves as a valuable reference point for plant cell biologists, molecular biologists, plant physiologists, biochemists, developmental biologists, and anyone interested in plant growth and development. The book is suitable for professionals in the field, students entering the field, and graduate students.\u003c\/p\u003e\u003cp\u003e                            \u003cstrong\u003eWeight\u003c\/strong\u003e: 730g                            \u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 234 x 156 (mm)                            \u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9780367782917                                                      \u003c\/p\u003e","brand":"Shulph Ink","offers":[{"title":"Paperback \/ softback","offer_id":44104730804474,"sku":"9780367782917","price":48.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/330c503634aa1e88338e44f4dd33a57e.jpg?v=1620649451"},{"product_id":"computational-biology-and-bioinformatics-gene-regulation","title":"Computational Biology and Bioinformatics: Gene Regulation","description":"\u003cp\u003e\u003c\/p\u003e\u003cblockquote\u003e Advances in biotechnology, such as next-generation sequencing technologies, are driving positive competition, but companion data analytical skills and computational methods are essential for making biotechnology-output data meaningful. This book collects state-of-the-art research works in computational biology and bioinformatics with a thematic focus on gene regulation, targeting senior undergraduates and junior graduate students in related disciplines. It will also serve as a useful reference for bioinformaticians and computational biologists in the post-genomic era. \u003c\/blockquote\u003e\u003cp\u003e                                                            \u003cstrong\u003eFormat\u003c\/strong\u003e: Paperback \/ softback\u003cbr\u003e                              \u003cstrong\u003eLength\u003c\/strong\u003e: 438 pages\u003cbr\u003e                              \u003cstrong\u003ePublication date\u003c\/strong\u003e: 31 March 2021\u003cbr\u003e                              \u003cstrong\u003ePublisher\u003c\/strong\u003e: Taylor \u0026amp; Francis Ltd\u003cbr\u003e                          \u003c\/p\u003e \u003cp\u003e Advances in biotechnology, such as next-generation sequencing technologies, are happening at an incredible pace. These advancements and breakthroughs provide competitive advantages to those who are prepared. However, the driving force behind the positive competition is not only limited to technological advancement but also to the companion data analytical skills and computational methods collectively known as computational biology and bioinformatics. Without these skills, the biotechnology-output data by itself is raw and perhaps meaningless. To raise awareness of this, we have collected the state-of-the-art research works in computational biology and bioinformatics with a thematic focus on gene regulation in this book. This book is designed to be self-contained and comprehensive, targeting senior undergraduates and junior graduate students in the related disciplines such as bioinformatics, computational biology, biostatistics, genome science, computer science, applied data mining, applied machine learning, life science, biomedical science, and genetics. 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It also examines multi-scale modeling efforts on prostate cancer growth and treatment dynamics, as well as mechanistically formulated models with applications to real tumors and validation using clinical data. \u003c\/blockquote\u003e\u003cp\u003e                                                            \u003cstrong\u003eFormat\u003c\/strong\u003e: Paperback \/ softback\u003cbr\u003e                              \u003cstrong\u003eLength\u003c\/strong\u003e: 472 pages\u003cbr\u003e                              \u003cstrong\u003ePublication date\u003c\/strong\u003e: 31 March 2021\u003cbr\u003e                              \u003cstrong\u003ePublisher\u003c\/strong\u003e: Taylor \u0026amp; Francis Ltd\u003cbr\u003e                          \u003c\/p\u003e \u003cp\u003e\u003cbr\u003eIntroduction to Mathematical Oncology provides biologically well-motivated and mathematically tractable models that facilitate both a deep understanding of cancer biology and better cancer treatment designs. It covers the medical and biological background of the diseases, modeling issues, and existing methods and their limitations. The authors introduce mathematical and programming tools, along with analytical and numerical studies of the models. They also develop new mathematical tools and look to future improvements on dynamical models.\u003cbr\u003e\u003cbr\u003eAfter introducing the general theory of medicine and exploring how mathematics can be essential in its understanding, the text describes well-known, practical, and insightful mathematical models of avascular tumor growth and mathematically tractable treatment models based on ordinary differential equations. It continues the topic of avascular tumor growth in the context of partial differential equation models by incorporating the spatial structure and physiological structure, such as cell size. The book then focuses on the recent active multi-scale modeling efforts on prostate cancer growth and treatment dynamics. It also examines more mechanistically formulated models, including cell quota-based population growth models, with applications to real tumors and validation using clinical data. The remainder of the text presents abundant additional historical, biological, and medical background materials for advanced and specific treatment modeling efforts.\u003cbr\u003e\u003cbr\u003eExtensively classroom-tested in undergraduate and graduate courses, this self-contained book allows instructors to emphasize specific topics relevant to clinical cancer biology and treatment. It can be used in a variety of ways, including a single-semester undergraduate course, a graduate-level course, or a research seminar.\u003cbr\u003e\u003cbr\u003eThe book begins with a brief overview of the history of mathematical oncology and its applications to cancer treatment. It then introduces the basic concepts of mathematical modeling, including differential equations, optimization, and simulation. The authors then discuss the medical and biological background of cancer, including the types of cancer, their causes, and their progression.\u003cbr\u003e\u003cbr\u003eNext, the book covers the modeling issues associated with cancer. These include the development of mathematical models that can accurately represent the behavior of cancer cells, the identification of the key parameters that govern cancer growth and progression, and the development of effective treatment strategies. The authors discuss the use of mathematical models to predict the response of cancer patients to different treatments, as well as to develop new treatments.\u003cbr\u003e\u003cbr\u003eThe book also covers the existing methods and their limitations. These include the use of chemotherapy, radiation therapy, and surgery, as well as the use of targeted therapies and immunotherapies. The authors discuss the advantages and disadvantages of each method and the challenges associated with their implementation.\u003cbr\u003e\u003cbr\u003eIn addition to the mathematical models, the book also includes analytical and numerical studies of the models. These studies help to validate the models and to identify the key parameters that govern cancer growth and progression. The authors use a variety of techniques, including finite difference methods, finite element methods, and Monte Carlo methods, to solve the mathematical models.\u003cbr\u003e\u003cbr\u003eThe book also develops new mathematical tools and looks to future improvements on dynamical models. These tools include the use of machine learning and artificial intelligence to improve the accuracy of cancer predictions and to develop new treatment strategies. The authors also discuss the use of personalized medicine to tailor treatment strategies to individual patients.\u003cbr\u003e\u003cbr\u003eFinally, the book presents abundant additional historical, biological, and medical background materials for advanced and specific treatment modeling efforts. These materials include case studies, clinical trials, and research papers. The authors provide detailed explanations of the methods used in these studies and the results obtained.\u003cbr\u003e\u003cbr\u003eIn conclusion, Introduction to Mathematical Oncology is a comprehensive and well-written book that provides biologically well-motivated and mathematically tractable models that facilitate both a deep understanding of cancer biology and better cancer treatment designs. It covers the medical and biological background of the diseases, modeling issues, and existing methods and their limitations. 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It covers principal components analysis, sparse principal component analysis, canonical correlation analysis, factor analysis, clustering, double clustering, and discriminant analysis, with examples in R and code and data available on the CRC Press web page. \u003c\/blockquote\u003e\u003cp\u003e                                                            \u003cstrong\u003eFormat\u003c\/strong\u003e: Paperback \/ softback\u003cbr\u003e                              \u003cstrong\u003eLength\u003c\/strong\u003e: 297 pages\u003cbr\u003e                              \u003cstrong\u003ePublication date\u003c\/strong\u003e: 31 March 2021\u003cbr\u003e                              \u003cstrong\u003ePublisher\u003c\/strong\u003e: Taylor \u0026amp; Francis Ltd\u003cbr\u003e                          \u003c\/p\u003e \u003cp\u003e\u003cbr\u003eRobust Methods for Data Reduction provides a comprehensive and non-technical introduction to robust data reduction techniques, emphasizing their practical applications. 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It provides a comprehensive overview of the methodology, possible applications, and risk assessment and regulatory issues involved in this field. \u003c\/blockquote\u003e\u003cp\u003e                                                            \u003cstrong\u003eFormat\u003c\/strong\u003e: Paperback \/ softback\u003cbr\u003e                              \u003cstrong\u003eLength\u003c\/strong\u003e: 424 pages\u003cbr\u003e                              \u003cstrong\u003ePublication date\u003c\/strong\u003e: 18 December 2020\u003cbr\u003e                              \u003cstrong\u003ePublisher\u003c\/strong\u003e: Taylor \u0026amp; Francis Ltd\u003cbr\u003e                          \u003c\/p\u003e \u003cp\u003eInsect Transgenesis: Methods and Applications is a groundbreaking publication that explores the various methodologies, possible applications, and risk assessment and regulatory issues involved in insect transgenesis. The book begins with an overview of the history and methodology of insect gene transfer, followed by gene targeting by homologous recombination and recombination systems, and systems for transgenic selection. Other sections consider the use of various vector systems to integrate DNA into a host genome or to express foreign genes in a host organism. The work concludes with strategies for the use of transgenic insects, including examples for agricultural pests and vectors of disease. Of particular interest are the final chapters that discuss risk assessment considerations and governmental regulatory procedures for the transport and release of transgenic insects.\u003cbr\u003e\u003c\/p\u003e\u003ch1\u003eInsect Transgenesis: Methods and Applications\u003c\/h1\u003e\u003cbr\u003e\u003cp\u003eInsect transgenesis is a revolutionary technique that allows scientists to control the transmission of certain diseases through the genetic modification of mosquitoes. By introducing specific genes into the mosquito genome, researchers can create mosquitoes that are resistant to the diseases they carry, such as malaria, dengue fever, and Zika virus. This approach eliminates the need for pesticides, which can have negative environmental impacts and pose risks to human health. Additionally, insect transgenesis can be used to increase the fertility of certain insects, which in turn can help to control the population of harmful arthropods or even plant pathogens. For example, researchers have developed genetically modified mosquitoes that are resistant to dengue fever and that produce offspring that are resistant to the disease. This approach has the potential to reduce the spread of dengue fever in endemic areas and to prevent outbreaks in new areas.\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eEradicating Harmful Insects\u003c\/h2\u003e\u003cbr\u003e\u003cp\u003eOne of the most significant applications of insect transgenesis is the eradication of harmful insects. Pesticides have been used for decades to control insect populations, but they can be harmful to both humans and the environment. Insect transgenesis offers a more sustainable and environmentally friendly alternative to pesticides. By introducing genes that confer resistance to pesticides into the mosquito genome, researchers can create mosquitoes that are resistant to the pesticides used in public health programs. This approach has been successful in several countries, including Brazil, where a genetically modified mosquito was released in 2015 to control the Aedes aegypti mosquito, which is responsible for transmitting dengue fever, Zika virus, and other diseases.\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eIncreasing Fertility of Insects\u003c\/h2\u003e\u003cbr\u003e\u003cp\u003eInsect transgenesis can also be used to increase the fertility of certain insects. This approach can be particularly useful in agriculture, where the productivity of crops is often limited by the availability of pollinators. By introducing genes that confer resistance to pesticides into the mosquito genome, researchers can create mosquitoes that are resistant to the pesticides used in public health programs. This approach has been successful in several countries, including Brazil, where a genetically modified mosquito was released in 2015 to control the Aedes aegypti mosquito, which is responsible for transmitting dengue fever, Zika virus, and other diseases.\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eReal-World Applications\u003c\/h2\u003e\u003cbr\u003e\u003cp\u003eInsect transgenesis has numerous real-world applications. For example, it can be used to improve agricultural productivity. By introducing genes that confer resistance to pests and diseases into the crop genome, researchers can create crops that are more resistant to pests and diseases. This approach has been successful in several countries, including Brazil, where a genetically modified rice was released in 2015 to control the rice blast disease.\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eRisk Assessment and Regulatory Issues\u003c\/h2\u003e\u003cbr\u003e\u003cp\u003eHowever, insect transgenesis also poses several risk assessment and regulatory issues. For example, the release of genetically modified insects into the environment can have unintended consequences. For example, genetically modified mosquitoes could spread to other areas and cause harm to non-target species. Additionally, the use of genetically modified insects in public health programs can raise ethical concerns.\u003cbr\u003e\u003c\/p\u003e\u003cp\u003eTo address these risk assessment and regulatory issues, researchers have developed a range of strategies. For example, they have developed genetically modified mosquitoes that are sterile or that have a limited lifespan. This approach can help to reduce the risk of the genetically modified insects spreading to other areas. Additionally, researchers have developed guidelines for the transport and release of genetically modified insects.\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eConclusion\u003c\/h2\u003e\u003cbr\u003e\u003cp\u003eInsect transgenesis is a revolutionary technique that offers substantial benefits to humankind. By controlling the transmission of certain diseases, increasing the fertility of certain insects, and improving agricultural productivity, insect transgenesis has the potential to transform the way we live. However, it also poses several risk assessment and regulatory issues that must be addressed. By developing strategies to address these issues, we can ensure that insect transgenesis is used in a safe and responsible manner.\u003cbr\u003e\u003c\/p\u003e\u003ch1\u003eInsect Transgenesis: Methods and Applications\u003c\/h1\u003e\u003cbr\u003e\u003cp\u003eInsect transgenesis is a revolutionary technique that allows scientists to control the transmission of certain diseases through the genetic modification of mosquitoes. By introducing specific genes into the mosquito genome, researchers can create mosquitoes that are resistant to the diseases they carry, such as malaria, dengue fever, and Zika virus. This approach eliminates the need for pesticides, which can have negative environmental impacts and pose risks to human health. Additionally, insect transgenesis can be used to increase the fertility of certain insects, which in turn can help to control the population of harmful arthropods or even plant pathogens. For example, researchers have developed genetically modified mosquitoes that are resistant to dengue fever and that produce offspring that are resistant to the disease. This approach has the potential to reduce the spread of dengue fever in endemic areas and to prevent outbreaks in new areas.\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eEradicating Harmful Insects\u003c\/h2\u003e\u003cbr\u003e\u003cp\u003eOne of the most significant applications of insect transgenesis is the eradication of harmful insects. Pesticides have been used for decades to control insect populations, but they can be harmful to both humans and the environment. Insect transgenesis offers a more sustainable and environmentally friendly alternative to pesticides. By introducing genes that confer resistance to pesticides into the mosquito genome, researchers can create mosquitoes that are resistant to the pesticides used in public health programs. This approach has been successful in several countries, including Brazil, where a genetically modified mosquito was released in 2015 to control the Aedes aegypti mosquito, which is responsible for transmitting dengue fever, Zika virus, and other diseases.\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eIncreasing Fertility of Insects\u003c\/h2\u003e\u003cbr\u003e\u003cp\u003eInsect transgenesis can also be used to increase the fertility of certain insects. This approach can be particularly useful in agriculture, where the productivity of crops is often limited by the availability of pollinators. By introducing genes that confer resistance to pesticides into the mosquito genome, researchers can create mosquitoes that are resistant to the pesticides used in public health programs. This approach has been successful in several countries, including Brazil, where a genetically modified mosquito was released in 2015 to control the Aedes aegypti mosquito, which is responsible for transmitting dengue fever, Zika virus, and other diseases.\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eReal-World Applications\u003c\/h2\u003e\u003cbr\u003e\u003cp\u003eInsect transgenesis has numerous real-world applications. For example, it can be used to improve agricultural productivity. By introducing genes that confer resistance to pests and diseases into the crop genome, researchers can create crops that are more resistant to pests and diseases. This approach has been successful in several countries, including Brazil, where a genetically modified rice was released in 2015 to control the rice blast disease.\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eRisk Assessment and Regulatory Issues\u003c\/h2\u003e\u003cbr\u003e\u003cp\u003eHowever, insect transgenesis also poses several risk assessment and regulatory issues. For example, the release of genetically modified insects into the environment can have unintended consequences. For example, genetically modified mosquitoes could spread to other areas and cause harm to non-target species. Additionally, the use of genetically modified insects in public health programs can raise ethical concerns.\u003cbr\u003e\u003c\/p\u003e\u003cp\u003eTo address these risk assessment and regulatory issues, researchers have developed a range of strategies. For example, they have developed genetically modified mosquitoes that are sterile or that have a limited lifespan. This approach can help to reduce the risk of the genetically modified insects spreading to other areas. Additionally, researchers have developed guidelines for the transport and release of genetically modified insects.\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eConclusion\u003c\/h2\u003e\u003cbr\u003e\u003cp\u003eInsect transgenesis is a revolutionary technique that offers substantial benefits to humankind. By controlling the transmission of certain diseases, increasing the fertility of certain insects, and improving agricultural productivity, insect transgenesis has the potential to transform the way we live. However, it also poses several risk assessment and regulatory issues that must be addressed. By developing strategies to address these issues, we can ensure that insect transgenesis is used in a safe and responsible manner.\u003c\/p\u003e\u003cp\u003e                            \u003cstrong\u003eWeight\u003c\/strong\u003e: 785g                            \u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 254 x 178 (mm)                            \u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9780367398385                                                      \u003c\/p\u003e","brand":"Shulph Ink","offers":[{"title":"Paperback \/ softback","offer_id":44104562901242,"sku":"9780367398385","price":64.72,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/52aadccf04f19fb6f7a08c1058231def.jpg?v=1620661471"},{"product_id":"stochastic-modeling-of-scientific-data","title":"Stochastic Modeling of Scientific Data","description":"\u003cp\u003e\n                                                            \u003cstrong\u003eFormat\u003c\/strong\u003e: Paperback \/ softback\u003cbr\u003e\n                              \u003cstrong\u003eLength\u003c\/strong\u003e: 384 pages\u003cbr\u003e\n                              \u003cstrong\u003ePublication date\u003c\/strong\u003e: 18 December 2020\u003cbr\u003e\n                              \u003cstrong\u003ePublisher\u003c\/strong\u003e: Taylor \u0026amp; Francis Ltd\u003cbr\u003e\n                          \u003c\/p\u003e\n                          \u003cp\u003e\u003c\/p\u003e\n                          \u003cp\u003e\n                            \u003cstrong\u003eWeight\u003c\/strong\u003e: 708g\n                            \u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 234 x 156 (mm)\n                            \u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9780367449001\n                            \n                          \u003c\/p\u003e","brand":"PeterGuttorp","offers":[{"title":"Paperback \/ softback","offer_id":44105031745786,"sku":"9780367449001","price":66.63,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/a1d8571305b55aefd93b1c87ce0d8fa7.jpg?v=1620661483"},{"product_id":"cilia-development-and-disease","title":"Cilia: Development and Disease","description":"\u003cp\u003e\u003c\/p\u003e\u003cblockquote\u003eThe book explores the diverse roles of cilia in human development and disease, highlighting their sensory, motility, and signaling functions and their association with defective development and human disease. It aims to bring together expertise from various fields to provide a medical and research context for postgraduate students, researchers, medics, and scientists. \u003c\/blockquote\u003e\u003cp\u003e                                                            \u003cstrong\u003eFormat\u003c\/strong\u003e: Paperback \/ softback\u003cbr\u003e                              \u003cstrong\u003eLength\u003c\/strong\u003e: 240 pages\u003cbr\u003e                              \u003cstrong\u003ePublication date\u003c\/strong\u003e: 31 March 2021\u003cbr\u003e                              \u003cstrong\u003ePublisher\u003c\/strong\u003e: Taylor \u0026amp; Francis Ltd\u003cbr\u003e                          \u003c\/p\u003e \u003cp\u003e\u003cbr\u003eCilia are tiny hair-like structures that protrude from the surface of cells in various parts of the body, including the brain, lungs, and reproductive organs. They play a crucial role in many biological processes, including the movement of fluids, the transport of nutrients, and the regulation of cell growth and division. However, cilia can also be involved in disease, and mutations in cilia genes can lead to a wide range of disorders, including blindness, deafness, and cystic fibrosis.\u003cbr\u003e\u003cbr\u003eThe book \"Cilia in Human Development and Disease\" aims to highlight the diverse roles of cilia in human development and disease. It covers a wide range of topics, including the structure and function of cilia, their role in sensory functions, motility, and signaling pathways, and their involvement in various human diseases. The book is written by experts in the field and is intended for postgraduate students, researchers, medics, and scientists.\u003cbr\u003e\u003cbr\u003eOne of the key aspects of the book is the emphasis on the importance of cilia in human development. Cilia are present in almost all cell types and play a critical role in the development of the nervous system, the lungs, and the reproductive organs. Mutations in cilia genes can lead to a wide range of developmental disorders, including blindness, deafness, and cystic fibrosis. The book provides a detailed overview of the mechanisms by which cilia contribute to development and discusses the potential therapeutic strategies that can be used to treat these disorders.\u003cbr\u003e\u003cbr\u003eIn addition to its focus on development, the book also covers the role of cilia in disease. Cilia can be involved in a wide range of diseases, including cancer, respiratory diseases, and neurological disorders. Mutations in cilia genes can lead to the formation of tumors, the development of respiratory diseases, and the impairment of neurological function. The book provides a detailed overview of the mechanisms by which cilia contribute to disease and discusses the potential therapeutic strategies that can be used to treat these disorders.\u003cbr\u003e\u003cbr\u003eOne of the challenges in studying cilia is the complexity of their structure and function. Cilia are composed of a microtubule-based structure that is surrounded by a membrane. The microtubules are responsible for the movement of fluids and the transport of nutrients, while the membrane is responsible for the regulation of cell growth and division. Mutations in cilia genes can lead to the formation of defective cilia, which can result in a wide range of disorders.\u003cbr\u003e\u003cbr\u003eTo address this challenge, the book provides a detailed overview of the techniques that can be used to study cilia. These techniques include electron microscopy, immunofluorescence, and genetic analysis. Electron microscopy allows researchers to visualize the structure of cilia at the nanometer level, while immunofluorescence allows researchers to identify the proteins that are present in cilia. Genetic analysis allows researchers to identify the genes that are responsible for cilia-related disorders.\u003cbr\u003e\u003cbr\u003eIn addition to its scientific content, the book also provides a practical guide for researchers and clinicians. It includes chapters on the diagnosis and treatment of cilia-related disorders, as well as chapters on the ethical and social implications of research on cilia. The book also includes a glossary of terms and a list of references for further reading.\u003cbr\u003e\u003cbr\u003eOne of the strengths of the book is its interdisciplinary nature. It brings together experts from a wide range of fields, including biology, medicine, and engineering, to provide a comprehensive overview of the role of cilia in human development and disease. This interdisciplinary approach allows researchers to develop new insights and approaches to the study of cilia and to develop new therapeutic strategies for cilia-related disorders.\u003cbr\u003e\u003cbr\u003eHowever, there are also some limitations to the book. One of the limitations is the lack of clinical data. While the book provides a detailed overview of the mechanisms by which cilia contribute to disease, it does not provide a comprehensive overview of the clinical outcomes of cilia-related disorders. This lack of clinical data can make it difficult for researchers and clinicians to develop effective therapeutic strategies for these disorders.\u003cbr\u003e\u003cbr\u003eAnother limitation is the cost of research on cilia. Research on cilia can be expensive, and many researchers and clinicians are unable to access the necessary equipment and resources. This can limit the progress of research on cilia and can prevent the development of new therapeutic strategies for cilia-related disorders.\u003cbr\u003e\u003cbr\u003eDespite these limitations, the book \"Cilia in Human Development and Disease\" is a valuable resource for researchers, medics, and scientists. It provides a comprehensive overview of the role of cilia in human development and disease and provides a practical guide for researchers and clinicians. The book is written by experts in the field and is intended for postgraduate students, researchers, medics, and scientists.\u003cbr\u003e\u003cbr\u003eIn conclusion, cilia are tiny hair-like structures that protrude from the surface of cells in various parts of the body. They play a crucial role in many biological processes, including the movement of fluids, the transport of nutrients, and the regulation of cell growth and division. However, cilia can also be involved in disease, and mutations in cilia genes can lead to a wide range of disorders. The book \"Cilia in Human Development and Disease\" aims to highlight the diverse roles of cilia in human development and disease and provides a practical guide for researchers and clinicians. While there are some limitations to the book, it is a valuable resource for researchers, medics, and scientists.\u003c\/p\u003e\u003cp\u003e                            \u003cstrong\u003eWeight\u003c\/strong\u003e: 467g                            \u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 234 x 156 (mm)                            \u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9780367781453                                                      \u003c\/p\u003e","brand":"Shulph Ink","offers":[{"title":"Paperback \/ softback","offer_id":44103964721402,"sku":"9780367781453","price":48.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/1a61013e049d4ffe1319b8c1dcb9be1f.jpg?v=1620661641"},{"product_id":"light-harvesting-in-photosynthesis","title":"Light Harvesting in Photosynthesis","description":"\u003cp\u003e\n                                                            \u003cstrong\u003eFormat\u003c\/strong\u003e: Paperback \/ softback\u003cbr\u003e\n                              \u003cstrong\u003eLength\u003c\/strong\u003e: 611 pages\u003cbr\u003e\n                              \u003cstrong\u003ePublication date\u003c\/strong\u003e: 31 March 2021\u003cbr\u003e\n                              \u003cstrong\u003ePublisher\u003c\/strong\u003e: Taylor \u0026amp; Francis Ltd\u003cbr\u003e\n                          \u003c\/p\u003e\n                          \u003cp\u003e\u003c\/p\u003e\n                          \u003cp\u003e\n                            \u003cstrong\u003eWeight\u003c\/strong\u003e: 1129g\n                            \u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 254 x 178 (mm)\n                            \u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9780367781491\n                            \n                          \u003c\/p\u003e","brand":"Shulph Ink","offers":[{"title":"Paperback \/ softback","offer_id":44104651571450,"sku":"9780367781491","price":50.44,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/a0e1624766a56502385e758b2959eb47.jpg?v=1620661662"},{"product_id":"bench-to-bedside-diagnostic-microbiology-for-the-clinicians","title":"Bench to Bedside: Diagnostic Microbiology for the Clinicians","description":"\u003cp\u003e\n                                                            \u003cstrong\u003eFormat\u003c\/strong\u003e: Paperback \/ softback\u003cbr\u003e\n                              \u003cstrong\u003eLength\u003c\/strong\u003e: 164 pages\u003cbr\u003e\n                              \u003cstrong\u003ePublication date\u003c\/strong\u003e: 31 March 2021\u003cbr\u003e\n                              \u003cstrong\u003ePublisher\u003c\/strong\u003e: Taylor \u0026amp; Francis Ltd\u003cbr\u003e\n                          \u003c\/p\u003e\n                          \u003cp\u003e\u003c\/p\u003e\n                          \u003cp\u003e\n                            \u003cstrong\u003eWeight\u003c\/strong\u003e: 318g\n                            \u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 234 x 156 (mm)\n                            \u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9780367781521\n                            \n                          \u003c\/p\u003e","brand":"Shulph Ink","offers":[{"title":"Paperback \/ softback","offer_id":44103687962874,"sku":"9780367781521","price":48.54,"currency_code":"GBP","in_stock":true}]},{"product_id":"glycobiology-and-human-diseases","title":"Glycobiology and Human Diseases","description":"\u003cp\u003e\u003c\/p\u003e\u003cblockquote\u003e\n\u003cbr\u003eGlycobiology and human diseases are explored in this book, covering topics such as immunoglobulins, inflammation, glycosylation, natural anti-glycan antibodies, urinary glycans, human milk glycobiology, and pectins as biological modulators. It provides analysis of comprehensive data and conclusions with perspectives. \u003c\/blockquote\u003e\u003cp\u003e                                                            \u003cstrong\u003eFormat\u003c\/strong\u003e: Paperback \/ softback\u003cbr\u003e                              \u003cstrong\u003eLength\u003c\/strong\u003e: 334 pages\u003cbr\u003e                              \u003cstrong\u003ePublication date\u003c\/strong\u003e: 31 March 2021\u003cbr\u003e                              \u003cstrong\u003ePublisher\u003c\/strong\u003e: Taylor \u0026amp; Francis Ltd\u003cbr\u003e                          \u003c\/p\u003e \u003cp\u003e\u003cbr\u003eGlycobiology is a fascinating field that explores the complex relationship between carbohydrates and human health. This book delves into various aspects of glycobiology, including immunoglobulins, inflammation, glycosylation, natural anti-glycan antibodies, urinary glycans, human milk glycobiology, and pectins as biological modulators of physiological reactions. By analyzing comprehensive data, the book provides valuable insights and conclusions that can help improve our understanding of glycobiology and its role in various diseases.\u003cbr\u003e\u003c\/p\u003e\u003ch1\u003eGlycobiology: A Comprehensive Guide to Human Diseases\u003c\/h1\u003e\u003cbr\u003e\u003cp\u003eGlycobiology is a branch of biology that studies the structure, function, and interactions of carbohydrates in living organisms. It plays a crucial role in various aspects of human health, including immunoglobulins, inflammation, glycosylation, and the therapeutic significance of natural anti-glycan antibodies in malignancies and normal and aberrant pregnancy. In this book, we will explore these topics in detail and discuss their implications for disease diagnosis and treatment.\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eImmunoglobulins and Glycosylation\u003c\/h2\u003e\u003cbr\u003e\u003cp\u003eImmunoglobulins are proteins that are produced by the immune system to fight against pathogens. They are composed of two heavy chains and two light chains, and each chain contains a variable region that can bind to specific antigens. Glycosylation is the process of adding sugar molecules to these proteins, which can affect their structure, function, and stability. Glycosylation can also be used to modify the immune response, making it more effective against pathogens.\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eInflammation and Glycosylation\u003c\/h2\u003e\u003cbr\u003e\u003cp\u003eInflammation is a natural response to injury or infection. It is characterized by the release of inflammatory mediators, such as cytokines, chemokines, and prostaglandins. Glycosylation can play a role in inflammation by affecting the expression of these mediators. For example, glycosylation can increase the expression of cytokines, which can lead to inflammation.\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eNatural Anti-Glycan Antibodies in Malignancies and Normal and Aberrant Pregnancy\u003c\/h2\u003e\u003cbr\u003e\u003cp\u003eNatural anti-glycan antibodies are antibodies that can bind to glycan structures on the surface of cells. They can be used to target and kill cancer cells. Natural anti-glycan antibodies have been shown to be effective in treating a variety of cancers, including leukemia, lymphoma, and breast cancer. They can also be used to treat normal and aberrant pregnancy, where they can help to prevent miscarriage and promote healthy pregnancy.\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eIdentifying Urinary Glycans as a Possible Method for the Diagnosis of Lysosomal Storage Diseases\u003c\/h2\u003e\u003cbr\u003e\u003cp\u003eUrinary glycans are a type of carbohydrate that is found in the urine. They can be used to diagnose lysosomal storage diseases, which are a group of genetic disorders that affect the metabolism of carbohydrates. Lysosomal storage diseases can cause a variety of symptoms, including muscle weakness, seizures, and cognitive impairment. By analyzing urinary glycans, researchers can identify the specific type of lysosomal storage disease that a patient has.\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003eGlycobiology of Human Milk\u003c\/h2\u003e\u003cbr\u003e\u003cp\u003eHuman milk is a rich source of carbohydrates, including lactose, galactose, and sialic acid. These carbohydrates are important for the growth and development of infants. Glycobiology of human milk has been studied extensively, and it has been shown to have a variety of biological roles and diseases. For example, lactose is important for the absorption of calcium and vitamin D, while galactose is important for the production of breast milk. Sialic acid is important for the immune system and the development of the brain.\u003cbr\u003e\u003c\/p\u003e\u003ch2\u003ePectins as Biological Modulators of Human Physiological Reactions\u003c\/h2\u003e\u003cbr\u003e\u003cp\u003ePectins are a type of carbohydrate that is found in fruits and vegetables. They are important for the regulation of the immune system and the regulation of blood pressure. Pectins can also be used to treat a variety of diseases, including cancer, heart disease, and diabetes. 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