{"product_id":"a-guide-to-sample-size-for-animalbased-studies-9781119799979","title":"A Guide to Sample Size for Animal-based Studies","description":"\u003cp\u003e\u003c\/p\u003e\u003cblockquote\u003eAnimal-based research is a crucial part of basic and preclinical research, but it poses unique experimental design challenges. This book provides a systematic approach to \"rightsizing\" animal-based experiments, with sample size estimates based on statistical thinking, to ensure scientifically valid and reliable results. It offers step-by-step guidance, detailed treatment of research topics, and numerous worked examples, making it a must-have reference for preclinical and veterinary researchers, ethical oversight committees, and policymakers. \u003c\/blockquote\u003e\u003cp\u003e\u003cstrong\u003eFormat\u003c\/strong\u003e: Paperback \/ softback\u003cbr\u003e\u003cstrong\u003eLength\u003c\/strong\u003e: 288 pages\u003cbr\u003e\u003cstrong\u003ePublication date\u003c\/strong\u003e: 22 September 2023\u003cbr\u003e\u003cstrong\u003ePublisher\u003c\/strong\u003e: John Wiley and Sons Ltd\u003cbr\u003e\u003c\/p\u003e \u003cp\u003e\u003cbr\u003eAnimal-based research is a crucial component of basic and preclinical studies, yet it presents unique challenges in experimental design. The three Rs, Replacement, Reduction, and Refinement, form the ethical framework for humane animal-based research. However, many researchers face difficulties in navigating the trade-offs between minimizing animal use and producing rigorous and reliable scientific information.\u003cbr\u003e\u003cbr\u003eA Guide to Sample Size for Animal-based Studies aims to address this need by providing a comprehensive and accessible reference work on the subject. This book offers a systematic approach to \"rightsizing\" animal-based experiments, utilizing statistical principles such as structured research questions, variation control, and appropriate experimental design. By following these guidelines, researchers can plan animal-based experiments to ensure scientifically valid and reliable results.\u003cbr\u003e\u003cbr\u003eThe book provides step-by-step guidance in diverse methods for approximating and refining sample size, covering topics specific to animal-based research, including pilot, feasibility, and proof-of-concept studies. It also discusses sample size approximation methods for different types of data and study types, such as description, comparison, nested designs, reference interval construction, and dose-response studies. Numerous worked examples, using real data from published papers, are included along with SAS and R code to facilitate practical implementation.\u003cbr\u003e\u003cbr\u003eA Guide to Sample Size for Animal-based Studies is a valuable resource for researchers, students, and professionals involved in animal-based research. It serves as a comprehensive guide to planning and executing animal-based experiments, ensuring the ethical and scientific use of animal subjects while maximizing the yield of valuable research findings.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWeight\u003c\/strong\u003e: 738g\u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 217 x 275 x 20 (mm)\u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9781119799979\u003c\/p\u003e","brand":"Penny S.Reynolds","offers":[{"title":"Paperback \/ softback","offer_id":44582531399930,"sku":"9781119799979","price":57.96,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/1695395080597_book.jpg?v=1695405827","url":"https:\/\/shulphink.com\/products\/a-guide-to-sample-size-for-animalbased-studies-9781119799979","provider":"Shulph Ink","version":"1.0","type":"link"}