{"product_id":"amide-bond-activation-concepts-and-reactions-9783527348312","title":"Amide Bond Activation - Concepts and Reactions","description":"\u003cp\u003e\u003c\/p\u003e\u003cblockquote\u003eThis book provides insights into the advances in amide bond activation, focusing on its structural properties and synthetic reactions. It is valuable for synthetic chemists in academia and the pharmaceutical industry to gain an in-depth understanding of this concept. \u003c\/blockquote\u003e\u003cp\u003e\u003cstrong\u003eFormat\u003c\/strong\u003e: Hardback\u003cbr\u003e\u003cstrong\u003eLength\u003c\/strong\u003e: 528 pages\u003cbr\u003e\u003cstrong\u003ePublication date\u003c\/strong\u003e: 09 November 2022\u003cbr\u003e\u003cstrong\u003ePublisher\u003c\/strong\u003e: Wiley-VCH Verlag GmbH\u003cbr\u003e\u003c\/p\u003e \u003cp\u003e\u003cbr\u003eThis comprehensive resource delves into the pivotal role of the amide bond in organic synthesis, offering insightful perspectives on the advancements made in this field. It focuses on both the fundamental structural properties of the amide bond and the synthetic reactions facilitated by transition metals. By discussing amide bond activation in the context of modern organic synthesis, the reader gains a thorough understanding of the area and its critical significance in forming carbon-carbon and carbon-heteroatom bonds. The work explores a range of sample topics, including:\u003cbr\u003eCross-coupling of amides: This involves the reaction of amides with other reactive molecules to form new compounds through the activation of the amide bond.\u003cbr\u003eAmide bond activation by twisting and nitrogen pyramidalization: This involves the manipulation of the amide bond through twisting or nitrogen pyramidalization reactions to enhance its reactivity and facilitate various synthetic transformations.\u003cbr\u003eElectrophilic amide bond functionalization: This involves the introduction of electrophilic groups onto the amide bond to modify its properties and enable specific reactions, such as nucleophilic substitution, Michael addition, and Heck reactions.\u003cbr\u003eTransition metal-catalyzed radical reactions of amides: This involves the use of transition metals to catalyze radical reactions of amides, such as nitrosylation, hydroxylation, and halogenation, leading to the formation of complex molecules.\u003cbr\u003eAmide bond esterification, hydrolysis, and transamidation: These reactions involve the modification of amide bonds through esterification, hydrolysis, and transamidation processes, which are important in drug discovery and materials science.\u003cbr\u003eClassical bridged lactams and anomeric amides: This section explores the synthesis and properties of classical bridged lactams and anomeric amides, which are important building blocks in organic chemistry.\u003cbr\u003eComputational studies of amide C-N bond activation: This involves the use of computational methods to study the activation of amide bonds and predict the reactivity and stereochemistry of various reaction intermediates.\u003cbr\u003eCross-coupling of esters by C-O activation: This section discusses the cross-coupling of esters with other reactive molecules through C-O activation reactions, which are important in organic synthesis and drug discovery.\u003cbr\u003eThis book is of immense value to synthetic chemists working in academia and the pharmaceutical industry, as it provides a deep understanding of the concept of amide bond activation. By exploring these various topics, the reader gains practical insights into the strategies and techniques used to enhance the reactivity and utility of amide bonds in organic synthesis.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWeight\u003c\/strong\u003e: 908g\u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 251 x 177 x 30 (mm)\u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9783527348312\u003c\/p\u003e","brand":"M Szostak","offers":[{"title":"Hardback","offer_id":44106041688314,"sku":"9783527348312","price":108.29,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/1669386798985_book.jpg?v=1669751181","url":"https:\/\/shulphink.com\/products\/amide-bond-activation-concepts-and-reactions-9783527348312","provider":"Shulph Ink","version":"1.0","type":"link"}