{"product_id":"biochemistry-and-cell-biology-of-ageing-part-iii-biomedical-science-9783031214097","title":"Biochemistry and Cell Biology of Ageing: Part III Biomedical Science","description":"\u003cp\u003e\u003c\/p\u003e\u003cblockquote\u003e\n\u003cbr\u003eThis book provides a comprehensive overview of key areas of subcellular aging research in human cells, covering microRNAs, circRNAs, mitochondria, extracellular vesicles, gap junctions, nuclear pore complex, and proteasome. It discusses novel therapeutic opportunities for modulation of cellular senescence and is a valuable resource for experienced researchers and early career scientists. \u003c\/blockquote\u003e\u003cp\u003e\u003cstrong\u003eFormat\u003c\/strong\u003e: Hardback\u003cbr\u003e\u003cstrong\u003eLength\u003c\/strong\u003e: 424 pages\u003cbr\u003e\u003cstrong\u003ePublication date\u003c\/strong\u003e: 06 January 2023\u003cbr\u003e\u003cstrong\u003ePublisher\u003c\/strong\u003e: Springer International Publishing AG\u003cbr\u003e\u003c\/p\u003e \u003cp\u003e\u003cbr\u003eThis comprehensive book offers a state-of-the-art overview of key areas of subcellular aging research in human cells. It delves into the historical development and progress in biomedical aging research, shedding light on the role of microRNAs, circRNAs, mitochondria, and extracellular vesicles in cellular senescence. The reader gains insights into how gap junctions, the nuclear pore complex, and the proteasome influence aging processes. Additionally, the book explores novel therapeutic opportunities through modulation of cellular senescence.\u003cbr\u003e\u003cbr\u003eFollowing the successful publication of Parts I and II of Biochemistry and Cell Biology of Aging (Volumes 90 and 91 of the Subcellular Biochemistry book series), this book expands the coverage of intriguing and significant biomedical aging topics. It serves as a valuable resource for both experienced researchers and early career scientists who are eager to delve deeper into the fascinating and challenging question of why and how our cells age.\u003cbr\u003e\u003cbr\u003eThe book is organized into chapters, each dedicated to exploring specific aspects of subcellular aging research. The first chapter provides an introduction to the field, highlighting the importance of studying aging processes and the potential for developing new therapies. The subsequent chapters delve into the role of microRNAs, circRNAs, mitochondria, and extracellular vesicles in cellular senescence.\u003cbr\u003e\u003cbr\u003eMicroRNAs, small non-coding RNAs, play a crucial role in regulating gene expression and cellular senescence. The book discusses the discovery of microRNAs and their involvement in various aging-related pathways. It explores how microRNAs can modulate the expression of proteins involved in DNA repair, inflammation, and cell cycle control, leading to cellular senescence.\u003cbr\u003e\u003cbr\u003eCircRNAs, another type of non-coding RNA, are also implicated in cellular senescence. The book discusses the biogenesis and function of circRNAs and their potential as biomarkers and therapeutic targets. It explores how circRNAs can regulate gene expression and interact with other cellular pathways, contributing to cellular senescence.\u003cbr\u003e\u003cbr\u003eMitochondria, the powerhouses of the cell, are also involved in cellular senescence. The book discusses the role of mitochondria in generating energy, regulating cellular metabolism, and contributing to oxidative stress. It explores how mitochondrial dysfunction and oxidative stress can lead to cellular senescence and the development of age-related diseases.\u003cbr\u003e\u003cbr\u003eExtracellular vesicles, small membrane-bound particles, play a significant role in intercellular communication and cellular senescence. The book discusses the biogenesis and function of extracellular vesicles and their potential as carriers of genetic material, proteins, and lipids. It explores how extracellular vesicles can regulate cellular senescence by transferring molecules between cells and promoting the formation of senescent cells.\u003cbr\u003e\u003cbr\u003eGap junctions, specialized intercellular junctions, are crucial for cell communication and tissue function. The book discusses the role of gap junctions in cellular senescence and their potential as therapeutic targets. It explores how gap junction dysfunction can lead to cellular senescence and the development of age-related diseases.\u003cbr\u003e\u003cbr\u003eThe nuclear pore complex, a complex structure that regulates gene expression, is also implicated in cellular senescence. The book discusses the structure and function of the nuclear pore complex and its potential as a therapeutic target. It explores how nuclear pore complex dysfunction can lead to cellular senescence and the development of age-related diseases.\u003cbr\u003e\u003cbr\u003eThe proteasome, a complex protein degradation machinery, plays a critical role in cellular senescence. The book discusses the role of the proteasome in protein turnover and its potential as a therapeutic target. It explores how proteasome dysfunction can lead to cellular senescence and the development of age-related diseases.\u003cbr\u003e\u003cbr\u003eIn addition to discussing the biological mechanisms of cellular senescence, the book also explores novel therapeutic opportunities through modulation of cellular senescence. It discusses the use of small molecules, genetic engineering, and stem cell therapy to slow down or reverse cellular senescence. It highlights the importance of understanding cellular senescence in developing personalized medicine for aging-related diseases.\u003cbr\u003e\u003cbr\u003eOverall, this comprehensive book provides a valuable resource for experienced researchers and early career scientists alike. It offers a thorough and up-to-date overview of key areas of subcellular aging research in human cells. The book is well-written, accessible, and filled with insightful information that will help readers better understand the complexities of cellular senescence and its implications for human health.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWeight\u003c\/strong\u003e: 816g\u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 235 x 155 (mm)\u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9783031214097\u003cbr\u003e \u003cstrong\u003eEdition number\u003c\/strong\u003e: 1st ed. 2023\u003c\/p\u003e","brand":"Shulph Ink","offers":[{"title":"Hardback","offer_id":44302323417338,"sku":"9783031214097","price":133.27,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/noImage_1_c79efacb-ba7f-47e5-8262-72e84a29c1cd.jpg?v=1687925179","url":"https:\/\/shulphink.com\/products\/biochemistry-and-cell-biology-of-ageing-part-iii-biomedical-science-9783031214097","provider":"Shulph Ink","version":"1.0","type":"link"}