{"product_id":"drug-transporters-molecular-characterization-and-role-in-drug-disposition-9781119737551","title":"Drug Transporters: Molecular Characterization and Role in Drug Disposition","description":"\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cblockquote\u003eDrug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition is a comprehensive textbook that provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. It covers basic knowledge, clinical outcomes, and emerging discoveries in transporter science and offers perspectives on future directions. It is an excellent textbook for pharmacological or physiological science courses and an invaluable reference for academic or industrial scientists working in the transporter field. \u003c\/blockquote\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eFormat\u003c\/strong\u003e: Hardback\u003cbr\u003e\u003cstrong\u003eLength\u003c\/strong\u003e: 576 pages\u003cbr\u003e\u003cstrong\u003ePublication date\u003c\/strong\u003e: 22 April 2022\u003cbr\u003e\u003cstrong\u003ePublisher\u003c\/strong\u003e: John Wiley and Sons Ltd\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003eDrug transporters play a crucial role in the transport of drugs across biological membranes, and their understanding is essential for drug discovery, development, and clinical applications. This comprehensive textbook provides an in-depth analysis of the fundamentals, principles, and techniques related to drug transporters. It covers various aspects, including the molecular characterization of drug transporters, their role in drug disposition, advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more.\u003cbr\u003e\u003cbr\u003eThe book is divided into two parts. The first part provides a thorough overview of relevant drug transporters, covering their classification, structure, function, and regulation. It also discusses the methods used to study drug transporters, including molecular biology techniques, cell culture studies, and in vivo animal models.\u003cbr\u003e\u003cbr\u003eThe second part delves into the principles of drug transport and associated techniques. It covers topics such as drug permeation, drug-transporting proteins, drug-efflux pumps, and drug-binding sites. The book also discusses the factors, including the factors that influence drug transport, the mechanisms of drug transport, and the factors that regulate drug transport.\u003cbr\u003e\u003cbr\u003eThe third edition of this textbook has been updated and expanded to include new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modeling, and the use of transporters as therapeutic targets for diseases.\u003cbr\u003e\u003cbr\u003eThe book reflects the current state of the field and offers perspectives on future directions. It covers basic knowledge, clinical outcomes, and emerging discoveries in transporter science. It provides up-to-date information on drug transporter families, mechanisms, and clinical implications.\u003cbr\u003e\u003cbr\u003eThe textbook includes extensive references and numerous figures and tables throughout, making it understandable for novices while offering sufficient depth for more experienced researchers. It is an excellent textbook for pharmacological or physiological science courses in drug\/membrane transport, and an invaluable reference for academic or industrial scientists.\u003cbr\u003e\u003cbr\u003eIn conclusion, Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition is a comprehensive and up-to-date textbook that provides a thorough understanding of drug transporters. It is an essential resource for pharmacological or physiological science courses, researchers, and practitioners in the field of drug discovery, development, and clinical applications.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWeight\u003c\/strong\u003e: 666g\u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 250 x 150 x 15 (mm)\u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9781119737551\u003cbr\u003e \u003cstrong\u003eEdition number\u003c\/strong\u003e: 3rd Edition\u003c\/p\u003e","brand":"Shulph Ink","offers":[{"title":"Hardback","offer_id":44106065838330,"sku":"9781119737551","price":186.48,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/1651838807884_book.jpg?v=1651902661","url":"https:\/\/shulphink.com\/products\/drug-transporters-molecular-characterization-and-role-in-drug-disposition-9781119737551","provider":"Shulph Ink","version":"1.0","type":"link"}