{"product_id":"inducing-targeted-protein-degradation-from-chemical-biology-to-drug-discovery-and-clinical-applications-9783527350131","title":"Inducing Targeted Protein Degradation - From Chemical Biology to Drug Discovery and Clinical Applications","description":"\u003cp\u003e\u003c\/p\u003e\u003cblockquote\u003e\n\u003cbr\u003eTargeted protein degradation has revolutionized drug discovery, allowing pharma companies to develop novel therapeutics. Inducing Targeted Protein Degradation is a comprehensive guide to navigating the complexities of the subject and understanding its practical application. It provides the most recent information on cellular mechanisms, approaches, drug development aspects, and the potential of targeted degradation for expanding the druggable space. \u003c\/blockquote\u003e\u003cp\u003e\u003cstrong\u003eFormat\u003c\/strong\u003e: Hardback\u003cbr\u003e\u003cstrong\u003eLength\u003c\/strong\u003e: 384 pages\u003cbr\u003e\u003cstrong\u003ePublication date\u003c\/strong\u003e: 28 December 2022\u003cbr\u003e\u003cstrong\u003ePublisher\u003c\/strong\u003e: Wiley-VCH Verlag GmbH\u003cbr\u003e\u003c\/p\u003e \u003cp\u003e\u003cbr\u003eSince the breakthrough of the PROTAC technology in 2015, targeted protein degradation has revolutionized drug discovery, enabling pharma companies to develop completely novel therapeutics.\u003cbr\u003e\u003cbr\u003eInducing Targeted Protein Degradation is a timely guide to navigating the complexities of the subject and understanding its practical application, with an eye on expanding the druggable space.\u003cbr\u003e\u003cbr\u003eIn Inducing Targeted Protein Degradation, readers will find the most recent information on:\u003cbr\u003e\u003cbr\u003eCellular mechanisms of targeted protein degradation and current approaches to utilize these mechanisms for drug discovery.\u003cbr\u003e\u003cbr\u003eA comparison of different induced degradation approaches, including PROTAC, molecular glues, LYTACs, and ATTECs, as well as additional post translational modifications.\u003cbr\u003e\u003cbr\u003eDrug development aspects such as DMPK optimization and criteria for the selection of clinical candidates.\u003cbr\u003e\u003cbr\u003eA discussion of the potential of targeted degradation for expanding the druggable space.\u003cbr\u003e\u003cbr\u003eInducing Targeted Protein Degradation will serve as a practice-oriented reference on induced protein degradation for drug discovery professionals and for researchers employing chemical biology approaches.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWeight\u003c\/strong\u003e: 892g\u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 177 x 252 x 26 (mm)\u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9783527350131\u003c\/p\u003e","brand":"P Cromm","offers":[{"title":"Hardback","offer_id":44106093854970,"sku":"9783527350131","price":96.69,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/1673606829830_book.jpg?v=1673940733","url":"https:\/\/shulphink.com\/products\/inducing-targeted-protein-degradation-from-chemical-biology-to-drug-discovery-and-clinical-applications-9783527350131","provider":"Shulph Ink","version":"1.0","type":"link"}