{"product_id":"phenotyping-of-human-ipscderived-neurons-patientdriven-research-9780128222775","title":"Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research","description":"\u003cp\u003e\u003c\/p\u003e\u003cblockquote\u003e\n\u003cbr\u003ePatient-Driven Research examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics. It presents example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, and provides suggestions for improvement. \u003c\/blockquote\u003e\u003cp\u003e\u003cstrong\u003eFormat\u003c\/strong\u003e: Paperback \/ softback\u003cbr\u003e\u003cstrong\u003eLength\u003c\/strong\u003e: 372 pages\u003cbr\u003e\u003cstrong\u003ePublication date\u003c\/strong\u003e: 15 September 2022\u003cbr\u003e\u003cstrong\u003ePublisher\u003c\/strong\u003e: Elsevier Science Publishing Co Inc\u003cbr\u003e\u003c\/p\u003e \u003cp\u003e\u003cbr\u003ePatient-Driven Research: Unlocking the Potential of iPSC-Derived Neurons in Understanding Neurological Disorders and Developing Novel Therapeutics\u003cbr\u003e\u003cbr\u003eThe field of phenotyping human iPSC-derived neurons has emerged as a powerful tool in the preclinical pipeline for better understanding neurological disorders and identifying novel therapeutics. This approach involves utilizing iPSC-derived neuronal technology to generate patient-specific neurons that can be used to model neurological conditions and test potential treatments.\u003cbr\u003e\u003cbr\u003eOne of the key advantages of patient-driven research is its ability to provide insights into the genetic and molecular mechanisms underlying neurological disorders. By generating iPSC-derived neurons from patients with specific disorders, researchers can study the cellular and molecular changes that occur in these cells and identify potential targets for therapeutic intervention.\u003cbr\u003e\u003cbr\u003eIn addition to understanding the underlying mechanisms of neurological disorders, patient-driven research can also be used to develop personalized treatments. By studying the genetic and molecular differences between patients with similar disorders, researchers can identify specific biomarkers that can be used to predict response to therapy and tailor treatment regimens accordingly.\u003cbr\u003e\u003cbr\u003eOne example of a patient-driven research project that has identified phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy is the work of Dr. Michael J. Fox and his team at the Michael J. Fox Foundation. Using iPSC-derived neurons from patients with these disorders, they have identified specific cellular and molecular changes that are associated with these conditions. This research has led to the development of new therapeutic strategies that are aimed at targeting these specific pathways.\u003cbr\u003e\u003cbr\u003eAnother example of a patient-driven research project is the work of Dr. David M. Holtzman and his team at the University of California, San Francisco. Using iPSC-derived neurons from patients with Parkinson's disease, they have identified specific cellular and molecular changes that are associated with this disorder. This research has led to the development of new therapeutic strategies that are aimed at mitigating the symptoms of Parkinson's disease.\u003cbr\u003e\u003cbr\u003eIn addition to identifying novel therapeutics, patient-driven research can also be used to improve the reproducibility and efficiency of the preclinical pipeline. By generating iPSC-derived neurons from multiple patients with the same disorder, researchers can compare and contrast the phenotypes and mechanisms of these cells and identify potential sources of variability. This information can then be used to improve the design and execution of future studies and improve the accuracy of drug discovery.\u003cbr\u003e\u003cbr\u003eOne of the challenges of patient-driven research is the need for large amounts of patient-specific data. This data can be difficult to collect and analyze, and it can be expensive and time-consuming. However, advances in technology, such as next-generation sequencing and single-cell analysis, have made it possible to generate and analyze large amounts of data quickly and efficiently.\u003cbr\u003e\u003cbr\u003eIn conclusion, phenotyping human iPSC-derived neurons has emerged as a powerful tool in the preclinical pipeline for better understanding neurological disorders and identifying novel therapeutics. By utilizing patient-specific neurons to model neurological conditions and test potential treatments, researchers can gain insights into the genetic and molecular mechanisms underlying these disorders and develop personalized treatments. In addition, patient-driven research can improve the reproducibility and efficiency of the preclinical pipeline and lead to the development of new therapeutic strategies that can improve the lives of patients with neurological disorders.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWeight\u003c\/strong\u003e: 806g\u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 192 x 234 x 24 (mm)\u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9780128222775\u003c\/p\u003e","brand":"Shulph Ink","offers":[{"title":"Paperback \/ softback","offer_id":44096411828474,"sku":"9780128222775","price":102.64,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/1667571788828_book.jpg?v=1668192678","url":"https:\/\/shulphink.com\/products\/phenotyping-of-human-ipscderived-neurons-patientdriven-research-9780128222775","provider":"Shulph Ink","version":"1.0","type":"link"}