{"product_id":"phospholipases-in-physiology-and-pathology-9780323956871","title":"Phospholipases in Physiology and Pathology","description":"\u003cp\u003e\u003c\/p\u003e\u003cblockquote\u003ePhospholipases are enzymes that regulate cell function and are dysregulated in various diseases. This seven-volume set explores their physiology and pathology, covering signal transduction, cancer, infectious diseases, neural diseases, cardiovascular diseases, inflammation, apoptosis, gene expression, and stem cell therapies. \u003c\/blockquote\u003e\u003cp\u003e\u003cstrong\u003eFormat\u003c\/strong\u003e: Mixed media product\u003cbr\u003e\u003cstrong\u003eLength\u003c\/strong\u003e: 1050 pages\u003cbr\u003e\u003cstrong\u003ePublication date\u003c\/strong\u003e: 01 August 2023\u003cbr\u003e\u003cstrong\u003ePublisher\u003c\/strong\u003e: Elsevier Science \u0026amp; Technology\u003cbr\u003e\u003c\/p\u003e \u003cp\u003e\u003cbr\u003ePhospholipases play a crucial role in both physiology and pathology, and their comprehensive understanding is essential for comprehending various diseases. This seven-volume set, titled \"Phospholipases in Physiology and Pathology,\" delves into the intricate mechanisms of normal and abnormal cell function in the context of dysregulation of phospholipases. Spanning across multiple volumes, the set explores diverse aspects such as signal transduction pathways, implications in cancer, infectious diseases, neural diseases, cardiovascular diseases, and other ailments. It also examines the role of phospholipases in inflammation, apoptosis, gene expression, non-coding RNAs, therapeutics, including stem cell therapies, nanotechnology-based approaches, and more. By consolidating these volumes, researchers gain invaluable insights into the mechanistic underpinnings and therapeutic potential of phospholipases, paving the way for developing innovative treatments and interventions for a wide range of medical conditions.\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eIntroduction:\u003c\/strong\u003e\u003cbr\u003ePhospholipases, a class of enzymes that hydrolyze phospholipid bilayers, are involved in numerous physiological and pathological processes. These enzymes play a vital role in signal transduction, cell membrane dynamics, and the regulation of cellular functions. Dysregulation of phospholipases can lead to various diseases, including cancer, infectious diseases, neurological disorders, and cardiovascular diseases.\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eSignaling Mechanisms:\u003c\/strong\u003e\u003cbr\u003ePhospholipases are involved in signal transduction pathways that regulate cellular responses to various stimuli. They are activated by specific ligands, such as hormones, growth factors, and neurotransmitters, and they produce signaling molecules that activate downstream signaling pathways. Dysregulation of phospholipases can disrupt these signaling pathways, leading to abnormal cell function and disease development.\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eImplications in Cancer:\u003c\/strong\u003e\u003cbr\u003ePhospholipases have been implicated in the development and progression of cancer. They are involved in the regulation of cell growth, survival, and migration, and they can modulate the activity of tumor suppressor genes and oncogenes. Dysregulation of phospholipases can contribute to the development of cancer by promoting cell proliferation, angiogenesis, and metastasis.\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eInfectious Diseases:\u003c\/strong\u003e\u003cbr\u003ePhospholipases are also involved in infectious diseases. They are produced by immune cells and bacteria and they play a role in the activation of immune responses and the destruction of infected cells. Dysregulation of phospholipases can contribute to the development of infectious diseases by impairing immune responses and promoting bacterial growth.\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eNeural Diseases:\u003c\/strong\u003e\u003cbr\u003ePhospholipases are involved in the development and progression of neurological disorders. They are involved in the regulation of neurotransmitter release, synaptic plasticity, and neuronal growth. Dysregulation of phospholipases can contribute to the development of neurological disorders such as Alzheimer's disease, Parkinson's disease, and stroke.\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eCardiovascular Diseases:\u003c\/strong\u003e\u003cbr\u003ePhospholipases are also involved in cardiovascular diseases. They are involved in the regulation of blood clotting, inflammation, and atherosclerosis. Dysregulation of phospholipases can contribute to the development of cardiovascular diseases by promoting blood clot formation, inflammation, and atherosclerosis.\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eTherapeutic Approaches:\u003c\/strong\u003e\u003cbr\u003eUnderstanding the role of phospholipases in disease development has led to the development of therapeutic approaches. One approach is the use of inhibitors that block the activity of specific phospholipases. These inhibitors have been used in the treatment of cancer, infectious diseases, and cardiovascular diseases. Another approach is the use of gene therapy that targets phospholipase genes or their signaling pathways. This approach has been used in the treatment of neurological disorders such as Alzheimer's disease.\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eConclusion:\u003c\/strong\u003e\u003cbr\u003eIn conclusion, phospholipases play a crucial role in both physiology and pathology. Their comprehensive understanding is essential for developing innovative treatments and interventions for various diseases. The seven-volume set \"Phospholipases in Physiology and Pathology\" provides a comprehensive overview of the biochemical and molecular mechanisms of normal and abnormal cell function upon dysregulation of phospholipases in different diseases. By consolidating these volumes, researchers gain invaluable insights into the mechanistic underpinnings and therapeutic potential of phospholipases, paving the way for developing new therapies and improving patient outcomes.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWeight\u003c\/strong\u003e: 450g\u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 234 x 191 (mm)\u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9780323956871\u003c\/p\u003e","brand":"Shulph Ink","offers":[{"title":"Mixed media product","offer_id":44526022754554,"sku":"9780323956871","price":499.12,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/noImage_1_ddeaf769-fc03-43ca-a4e8-9b0517c6a25e.jpg?v=1693394474","url":"https:\/\/shulphink.com\/products\/phospholipases-in-physiology-and-pathology-9780323956871","provider":"Shulph Ink","version":"1.0","type":"link"}