{"product_id":"proteostasis-and-proteolysis-9780367499334","title":"Proteostasis and Proteolysis","description":"\u003cp\u003e\u003c\/p\u003e\u003cblockquote\u003e\n\u003cbr\u003eProteostasis controls protein biogenesis, trafficking, folding, and degradation, and this book focuses on two protein breakdown\/degradation processes: the ubiquitin-proteasome system and autophagy. Chapter 2 is available for free download. \u003c\/blockquote\u003e\u003cp\u003e\u003cstrong\u003eFormat\u003c\/strong\u003e: Paperback \/ softback\u003cbr\u003e\u003cstrong\u003eLength\u003c\/strong\u003e: 251 pages\u003cbr\u003e\u003cstrong\u003ePublication date\u003c\/strong\u003e: 29 January 2024\u003cbr\u003e\u003cstrong\u003ePublisher\u003c\/strong\u003e: Taylor \u0026amp; Francis Ltd\u003cbr\u003e\u003c\/p\u003e \u003cp\u003e\u003cbr\u003eProteostasis is a complex web of biological pathways that orchestrate the intricate processes of protein biogenesis, trafficking, folding, and degradation. Within this intricate network, two crucial protein breakdown\/degradation processes come to the forefront: proteolysis, which forms an integral part of a well-functioning proteostatic system.\u003cbr\u003e\u003cbr\u003eProteolysis refers to the breakdown of proteins into smaller fragments through the action of enzymes known as proteases. These proteases play a vital role in various cellular functions, including tissue remodeling, immune response, and the regulation of protein levels. There are two main types of proteolysis: autolytic and non-autolytic. Autolytic proteolysis occurs within the cell, utilizing the cell's own enzymes, while non-autolytic proteolysis requires the involvement of external proteases.\u003cbr\u003e\u003cbr\u003eOne of the most well-studied proteolytic systems is the ubiquitin-proteasome system. This intricate pathway involves the covalent attachment of ubiquitin molecules to target proteins, marking them for degradation by the proteasome. Ubiquitin is a small protein that can be added to proteins in a three-step process: activation, conjugation, and degradation. The ubiquitin-proteasome system plays a critical role in regulating protein stability, turnover, and cellular signaling.\u003cbr\u003e\u003cbr\u003eAutophagy is another important protein breakdown\/degradation process. During autophagy, the cell engulfs its own components, including damaged organelles, protein aggregates, and cytoplasmic debris. The engulfed material is then transported to a specialized compartment called the lysosome, where it is broken down by enzymes. Autophagy is a vital mechanism for cellular homeostasis, as it helps to clear away waste products and maintain the proper functioning of cellular processes.\u003cbr\u003e\u003cbr\u003eIn conclusion, proteostasis is a dynamic and intricate process that involves the coordination of multiple biological pathways to control protein biogenesis, trafficking, folding, and degradation. Proteolysis, specifically autolytic and non-autolytic proteolysis, plays a crucial role in maintaining cellular homeostasis and regulating various cellular processes. The ubiquitin-proteasome system and autophagy are two prominent protein breakdown\/degradation processes that are integral to a healthy and functioning proteostatic system.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWeight\u003c\/strong\u003e: 453g\u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 254 x 178 (mm)\u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9780367499334\u003c\/p\u003e","brand":"Shulph Ink","offers":[{"title":"Paperback \/ softback","offer_id":45179498823930,"sku":"9780367499334","price":49.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/noImage_1_844376bc-75fb-45a3-ba61-c18523984cb6.jpg?v=1707754510","url":"https:\/\/shulphink.com\/products\/proteostasis-and-proteolysis-9780367499334","provider":"Shulph Ink","version":"1.0","type":"link"}