{"product_id":"sequencespecific-dna-binders-for-the-therapy-of-mitochondrial-diseases-9789811684388","title":"Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases","description":"\u003cp\u003e\u003c\/p\u003e\u003cblockquote\u003e\n\u003cbr\u003eThe author's research focuses on developing sequence-specific DNA binders for the therapy of mitochondrial diseases. The developed compounds, called MITO-PIPs, recognize specific sequences in mitochondrial DNA and can reduce the copy number of mutated mitochondrial DNA in live cells. Tri-arginine vectors can enhance nuclear uptake of PIPs and improve their biological activity. This work paves the way for a transgene-free chemical gene therapy for mitochondrial diseases. \u003c\/blockquote\u003e\u003cp\u003e\u003cstrong\u003eFormat\u003c\/strong\u003e: Paperback \/ softback\u003cbr\u003e\u003cstrong\u003eLength\u003c\/strong\u003e: 94 pages\u003cbr\u003e\u003cstrong\u003ePublication date\u003c\/strong\u003e: 05 January 2023\u003cbr\u003e\u003cstrong\u003ePublisher\u003c\/strong\u003e: Springer Verlag, Singapore\u003cbr\u003e\u003c\/p\u003e \u003cp\u003e\u003cbr\u003eThis book delves into the author's groundbreaking work in developing sequence-specific DNA binders for the treatment of mitochondrial diseases. In the opening chapter, the author provides a comprehensive background on pyrrole–imidazole polyamides (PIPs) and mitochondrial disease research, paving the way for subsequent chapters that showcase the author's own research and discoveries.\u003cbr\u003e\u003cbr\u003eThe author introduces the concept of MITO-PIPs, compounds specifically designed to recognize and bind to specific sequences in mitochondrial DNA. The following chapter showcases the remarkable ability of MITO-PIPs to reduce the copy number of mutated mitochondrial DNA in live cells. By incorporating a DNA alkylating reagent into a MITO-PIP that recognizes the adjacent sequence to a target mutation, the author achieves a successful reduction in the mutated DNA.\u003cbr\u003e\u003cbr\u003eRecognizing the importance of targeting nuclear DNA as well for treating mitochondrial diseases, the author demonstrates the use of tri-arginine vectors to enhance the nuclear uptake of PIPs and improve their biological activity in cells. This groundbreaking work holds significant promise for the development of a transgene-free chemical gene therapy for mitochondrial disorders.\u003cbr\u003e\u003cbr\u003eThe book is meticulously detailed, providing a comprehensive description of experimental procedures, particularly compound synthesis. This detailed account aids readers in gaining a clear understanding of the author's studies and empowers them to conduct similar and extended research endeavors.\u003cbr\u003e\u003cbr\u003eOverall, this book is a valuable resource for researchers and clinicians interested in exploring innovative approaches to treating mitochondrial diseases. The author's groundbreaking work in developing sequence-specific DNA binders holds the potential to revolutionize the field of mitochondrial medicine.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWeight\u003c\/strong\u003e: 180g\u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 235 x 155 (mm)\u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9789811684388\u003cbr\u003e \u003cstrong\u003eEdition number\u003c\/strong\u003e: 1st ed. 2022\u003c\/p\u003e","brand":"Takuya Hidaka","offers":[{"title":"Paperback \/ softback","offer_id":44302317027578,"sku":"9789811684388","price":108.28,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/noImage_1_6ea316ee-941a-4de4-aac7-7b620e7a964b.jpg?v=1687925031","url":"https:\/\/shulphink.com\/products\/sequencespecific-dna-binders-for-the-therapy-of-mitochondrial-diseases-9789811684388","provider":"Shulph Ink","version":"1.0","type":"link"}