{"product_id":"the-functional-roles-of-histamine-receptors-9783031169960","title":"The Functional Roles of Histamine Receptors","description":"\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cblockquote\u003e\n\u003cbr\u003eOver the past 100 years, research in histamine receptors has revolutionized the clinical approach to treating allergies and gastrointestinal ailments, leading to the development of new pharmacological treatments for peptic ulcer and gastroesophageal reflux. The discovery of another histamine receptor, number 4, using genomics-based reverse pharmacological approaches has raised hopes for its translational exploitation as a new therapeutic target for unmet medical needs. However, further research is needed to better understand receptor intra- and interspecies heterogeneity and to develop new histaminergic ligands. This book aims to provide a comprehensive overview of the preclinical and clinical advances made in recent decades and the exciting prospects for the future of histamine receptor function and pharmacology in the central nervous system. \u003c\/blockquote\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eFormat\u003c\/strong\u003e: Hardback\u003cbr\u003e\u003cstrong\u003eLength\u003c\/strong\u003e: 468 pages\u003cbr\u003e\u003cstrong\u003ePublication date\u003c\/strong\u003e: 30 September 2022\u003cbr\u003e\u003cstrong\u003ePublisher\u003c\/strong\u003e: Springer International Publishing AG\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cbr\u003eOver the past century, significant strides have been made in the field of histamine receptors, which have played a pivotal role in the development of modern pharmacology. Pioneering research led by exceptional scientists has revolutionized the clinical approach to treating allergies and gastrointestinal ailments. The pharmacological treatment of peptic ulcer and gastroesophageal reflux has been a game-changer, as it has eliminated the need for surgical intervention.\u003cbr\u003e\u003cbr\u003eHowever, the quest for new therapeutic targets in histamine pharmacology has encountered several challenges. The discovery of another histamine receptor, number 4, using genomics-based reverse pharmacological approaches for screening orphan GPCRs has rekindled interest in this field. This receptor is preferentially expressed by immune cells and holds great promise for developing novel therapeutics for a wide range of medical conditions, from asthma to cancer.\u003cbr\u003e\u003cbr\u003eDespite these promising developments, several obstacles have hindered progress in histamine research. A better understanding of receptor intra- and interspecies heterogeneity is crucial for translating experimental data into clinical practice. Additionally, the vast amount of data available on brain histamine suggests that this system plays a fundamental role in receiving and processing internal and peripheral stimuli to allocate the necessary excitation to specific brain circuits that govern appropriate behavioral responses.\u003cbr\u003e\u003cbr\u003eThe development of new histaminergic ligands is an ongoing endeavor that continues to provide valuable preclinical tools. The aim of this book is to provide a comprehensive overview of histamine receptor function and pharmacology in the central nervous system. It highlights the clinical and preclinical advancements made in recent decades and explores the exciting prospects for the future. By exploring the complexities of histamine receptors, this book aims to shed light on the potential for new treatments and therapies that can improve the lives of individuals suffering from various medical conditions.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWeight\u003c\/strong\u003e: 881g\u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 235 x 155 (mm)\u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9783031169960\u003cbr\u003e \u003cstrong\u003eEdition number\u003c\/strong\u003e: 1st ed. 2022\u003c\/p\u003e","brand":"Shulph Ink","offers":[{"title":"Hardback","offer_id":44272401154298,"sku":"9783031169960","price":108.28,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/noImage_1_d0b42274-f636-400b-895e-b7de65867230.jpg?v=1686253358","url":"https:\/\/shulphink.com\/products\/the-functional-roles-of-histamine-receptors-9783031169960","provider":"Shulph Ink","version":"1.0","type":"link"}