{"product_id":"the-gliocentric-brain-9783031481079","title":"The Gliocentric Brain: Phenotype Plasticity of the Damaged Brain","description":"The brain is the body’s most vulnerable organ due to the defined roles of neurons within circuits. Neurons are vastly outnumbered by microglia, astrocytes, oligodendrocytes, macrophages, cells of the blood brain barrier and invading immune cells. These cells display different grades of reactivities and interactions. They integrate their responses and not only change phenotypes but can also completely reprogram after damage to protect the neuronal complexity. The interactions of these satellite cells in the healthy brain are described as well as their roles in all major brain diseases. Special emphasis is put on immune system – brain interactions and regenerative and repair processes. The gliotic response is compared with the reactions to injuries of the skin and other organs. A final chapter addresses the definition of a cell type. It concludes that cell types can no longer be regarded as defined entities over the body’s lifetime but are prone to phenotype plasticity and even completereprograming.\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePublication date:\u003c\/strong\u003e 26 January 2025\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePage count:\u003c\/strong\u003e 249\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDimensions:\u003c\/strong\u003e Height 235 mm; Width 155 mm\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePublisher:\u003c\/strong\u003e Springer International Publishing AG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Paperback\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eISBN-13:\u003c\/strong\u003e 9783031481079\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Wolfgang Walz","offers":[{"title":"Paperback","offer_id":50207398854906,"sku":"9783031481079","price":115.63,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/files\/9783031481079.jpg?v=1788226075","url":"https:\/\/shulphink.com\/products\/the-gliocentric-brain-9783031481079","provider":"Shulph Ink","version":"1.0","type":"link"}