{"product_id":"the-immunological-synapse-part-b-9780443191633","title":"The Immunological Synapse - Part B","description":"\u003cp\u003e\u003c\/p\u003e\u003cblockquote\u003eThe Methods in Cell Biology series' Immunological Synapse - Part B,Volume 178 offers cutting-edge techniques for studying T cell and natural killer (NK) cell synapses, such as imaging polarized granule release, analyzing actin reorganization, and quantifying interactions. It also covers proteomic analysis, NK-tumor cell interaction, CAR-modified cell immunological synapse quality, and potency monitoring of therapeutic CAR T cells. \u003c\/blockquote\u003e\u003cp\u003e\u003cstrong\u003eFormat\u003c\/strong\u003e: Hardback\u003cbr\u003e\u003cstrong\u003eLength\u003c\/strong\u003e: 318 pages\u003cbr\u003e\u003cstrong\u003ePublication date\u003c\/strong\u003e: 14 July 2023\u003cbr\u003e\u003cstrong\u003ePublisher\u003c\/strong\u003e: Elsevier Science Publishing Co Inc\u003cbr\u003e\u003c\/p\u003e \u003cp\u003e\u003cbr\u003eThe Immunological Synapse - Part B,Volume 178 in the Methods in Cell Biology series is a comprehensive resource for studying the intricate mechanisms of the immunological synapse. This first volume delves into diverse aspects of T cell and natural killer (NK) cell synapses, encompassing imaging polarized granule release using TIRF microscopy, analyzing actin reorganization and centrosome polarization, investigating redirected degranulation, employing live cell-imaging to quantify cytotoxic and chemotactic dynamics, quantifying interactions between antigen-presenting cells (APCs) and T cells, assessing the membrane lipid state at the immunological synapse, conducting proteomic analysis and imaging of NK-tumor cell interactions, evaluating natural killer cell effector functions against breast cancer cells derived from human tumor tissue, examining the quality of chimeric antigen receptor (CAR)-modified cell immunological synapses using the glass-supported planar lipid bilayer, and monitoring the potency of therapeutic CAR T cells. Additionally, the book includes two chapters on quantifying lymphocytic choriomeningitis virus (LCMV)-specific T cells and LCMV viral titers, as well as one chapter on the murine antibody-dependent cellular phagocytosis assay.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003eThe Immunological Synapse - Part B,Volume 178 in the Methods in Cell Biology series is a comprehensive resource for studying the intricate mechanisms of the immunological synapse.\u003c\/p\u003e\u003cp\u003eThis first volume delves into diverse aspects of T cell and natural killer (NK) cell synapses, encompassing imaging polarized granule release using TIRF microscopy, analyzing actin reorganization and centrosome polarization, investigating redirected degranulation, employing live cell-imaging to quantify cytotoxic and chemotactic dynamics, quantifying interactions between antigen-presenting cells (APCs) and T cells, assessing the membrane lipid state at the immunological synapse, conducting proteomic analysis and imaging of NK-tumor cell interactions, evaluating natural killer cell effector functions against breast cancer cells derived from human tumor tissue, examining the quality of chimeric antigen receptor (CAR)-modified cell immunological synapses using the glass-supported planar lipid bilayer, and monitoring the potency of therapeutic CAR T cells.\u003c\/p\u003e\u003cp\u003eAdditionally, the book includes two chapters on quantifying lymphocytic choriomeningitis virus (LCMV)-specific T cells and LCMV viral titers, as well as one chapter on the murine antibody-dependent cellular phagocytosis assay.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWeight\u003c\/strong\u003e: 450g\u003cbr\u003e\u003cstrong\u003eDimension\u003c\/strong\u003e: 229 x 152 (mm)\u003cbr\u003e\u003cstrong\u003eISBN-13\u003c\/strong\u003e: 9780443191633\u003c\/p\u003e","brand":"Shulph Ink","offers":[{"title":"Hardback","offer_id":44368177692922,"sku":"9780443191633","price":161.38,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0522\/4297\/2845\/products\/1689940022200_book.jpg?v=1689962233","url":"https:\/\/shulphink.com\/products\/the-immunological-synapse-part-b-9780443191633","provider":"Shulph Ink","version":"1.0","type":"link"}