A Handbook of Gene and Cell Therapy

Gene therapy is a set of strategies modifying gene expression or correcting mutant/defective genes through the administration of DNA (or RNA) to cells, to treat disease. This reference handbook covers important advances, such as RNA interference, the Human Genome project, iPSc, and the basics of gene therapy, and is a great resource for students, teachers, and biomedical researchers.

Format: Paperback / softback
Length: 188 pages
Publication date: 28 June 2021
Publisher: Springer Nature Switzerland AG

This comprehensive reference handbook is designed to guide young researchers embarking on the fascinating field of gene and cell therapy. Gene therapy, a revolutionary approach, involves the manipulation of gene expression or the correction of mutant or defective genes by introducing DNA (or RNA) into cells. Its potential lies in treating a wide range of diseases, making it a promising avenue for medical advancements.

Key breakthroughs, such as the discovery of RNA interference, the completion of the Human Genome project, and the development of induced pluripotent stem cells (iPSc), have propelled gene therapy forward. This handbook provides a solid foundation for students, teachers, biomedical researchers, and researchers seeking to leverage skills from this interdisciplinary field.

The first chapter delves into the basics of gene therapy, covering key concepts such as gene expression, DNA structure, and the mechanisms involved in gene transfer. It also introduces the different types of gene therapy approaches, including viral vectors, gene editing techniques, and stem cell-based therapies.

In the subsequent chapters, the handbook explores the application of gene therapy in specific disease areas. It discusses the treatment of genetic disorders such as cystic fibrosis, sickle cell anemia, and Huntington's disease, highlighting the successes and challenges encountered in these endeavors. The authors also delve into the potential of gene therapy for non-genetic diseases, such as cancer and heart disease, discussing the challenges and opportunities in developing effective therapies.

Throughout the book, real-world case studies and examples are provided to illustrate the practical implications of gene therapy. These case studies showcase the impact of gene therapy on patients' lives and provide valuable insights into the ethical considerations and regulatory frameworks surrounding this field.

In conclusion, this reference handbook is an invaluable resource for young researchers seeking to delve into the world of gene and cell therapy. It provides a comprehensive and up-to-date overview of the field, covering the fundamental principles, clinical applications, and emerging trends. Whether you are a student, teacher, biomedical researcher, or researcher exploring new fields, this handbook will serve as a valuable guide and catalyst for your journey into this exciting and rapidly evolving scientific domain.

Weight: 454g
Dimension: 254 x 178 (mm)
ISBN-13: 9783030413354
Edition number: 1st ed. 2020