Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics

Drs. Sverre Heim and Felix Mitelman's book, "Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics," provides an in-depth review of how cancer cytogenetic analyses have contributed to an improved understanding of tumorigenesis, diagnosis, and treatment. It also discusses how cytogenetics meets, interacts with, and cross-fertilizes other investigative technologies, such as molecular somatic cell genetics. The book offers readers a thorough introduction to ancient theories of disease, the advent of cellular pathology, and how a scientific interest in chromosomes developed. It also explores the conceptual importance of Theodor Boveri and his somatic mutation theory of cancer, a chronological resume of cancer cytogenetic discoveries, and in-depth discussions of the role of chromosome abnormalities, oncogenes, and tumor suppressor genes in leukemias, lymphomas, and solid tumors. The book is written for everyone with a scientific or clinical interest in cancer, especially how acquired chromosome abnormalities lead to neoplastic transformation.

Format: Hardback
Length: 208 pages
Publication date: 10 March 2022
Publisher: John Wiley and Sons Ltd

In their groundbreaking work, "Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics," Drs. Sverre Heim and Felix Mitelman, esteemed researchers of international repute, delve into the profound realm of cancer cytogenetics, shedding light on its historical significance, current applications, and promising prospects for the future. This comprehensive review explores how cancer cytogenetic analyses have revolutionized our understanding of tumorigenesis, aiding in the accurate diagnosis and personalized treatment of cancer patients.

The book delves into the intricate relationship between cytogenetics, the study of chromosomes, and other cutting-edge investigative technologies, such as molecular somatic cell genetics. It highlights the synergistic interplay between these disciplines, fostering a deeper comprehension of the role chromosomes play in health and disease, particularly in neoplastic disorders.

The authors provide a comprehensive introduction to the historical foundations of cytogenetics, tracing its origins back to ancient theories of disease and the emergence of cellular pathology. They also delve into the pioneering work of Theodor Boveri, a scientist who laid the theoretical groundwork for the study of somatic mutations and their role in cancer development.

The book offers a chronological resume of cancer cytogenetic discoveries throughout the 20th century, highlighting pivotal milestones and breakthroughs that have shaped our understanding of the disease. It explores the role of chromosome abnormalities, oncogenes, and tumor suppressor genes in leukemias, lymphomas, and solid tumors, shedding light on their mechanisms of action and their implications for cancer diagnosis and treatment.

Furthermore, the book delves into the significance of chromosome analyses in understanding the clonal evolution of neoplastic cell populations. It discusses the role of genetic heterogeneity in tumor progression and the potential for personalized medicine based on individual patient's genetic profiles.

In conclusion, "Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics" is a seminal work that provides a comprehensive and authoritative exploration of the field. By unraveling the complexities of cancer cytogenetics, the book empowers readers with a deeper understanding of the disease and its potential for personalized treatment. As we continue to advance in our understanding of cancer genetics, this book serves as a valuable resource for researchers, clinicians, and patients alike.

Weight: 468g
Dimension: 156 x 235 x 17 (mm)
ISBN-13: 9781119651987