Acute Kidney Injury and Regenerative Medicine

The book discusses the clinical-pathophysiological features of acute renal injury and highlights the importance of AKI in clinical settings, including differential diagnoses and management. It also presents novel experimental findings in regenerative medicine.

Format: Paperback / softback
Length: 396 pages
Publication date: 16 May 2021
Publisher: Springer Verlag, Singapore

The clinical-pathophysiological features of acute renal injury (AKI) are presented in this comprehensive book, along with an in-depth discussion of the KDIGO diagnostic criteria and novel experimental findings in the field of regenerative medicine. AKI's clinical-pathophysiological significance in clinical settings, including differential diagnoses and management strategies, is also emphasized.

In the past, sudden renal impairment was commonly referred to as acute renal failure (ARF). However, a significant shift occurred in the understanding of this pathology in the 2000s. This transformation was driven by the collaborative efforts of specialists from various fields, including nephrology, intensive care medicine, and cardiovascular medicine. As medical advancements progressed, patients who were previously considered non-candidates for invasive therapy were admitted to intensive care units (ICUs). Consequently, kidney injury, which was once viewed as a subset of multiple organ failure, was re-evaluated as AKI, particularly in the realm of intensive care medicine. AKI was introduced as a novel disease concept to underscore the critical importance of early diagnosis and timely intervention in improving prognosis.

This book offers a wealth of novel features, encompassing the definition of AKI, risk factors associated with its development, and comprehensive management strategies. It also delves into the use of biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP), which have proven to be valuable in the early detection and assessment of AKI. Furthermore, the book explores long-term outcomes of AKI, including its impact on patient survival and quality of life. Additionally, it discusses innovative approaches to renal regeneration, including the use of induced pluripotent stem cells (iPS cells), embryonic gene manipulation, and Xenotransplanted embryonic kidney.

This book is of immense interest to all physicians and researchers engaged in the field of acute renal injury worldwide. Its up-to-date information and comprehensive coverage make it an invaluable resource for those seeking to stay abreast of the latest developments and advancements in this rapidly evolving area of medicine.

Weight: 678g
Dimension: 155 x 234 x 24 (mm)
ISBN-13: 9789811511103
Edition number: 1st ed. 2020