Advances and Challenges in Pharmaceutical Technology: Materials, Process Development and Drug Delivery Strategies

Advancements and Challenges in Pharmaceutical Technology: Materials, Process Development, and Drug Delivery Strategies explores recent advancements in pharmaceutical technology, including formulation strategies, process analytical technology, and biomaterials, to develop pharmaceutical dosage forms.

Format: Paperback / softback
Length: 568 pages
Publication date: 10 February 2021
Publisher: Elsevier Science Publishing Co Inc

Pharmaceutical Technology: Materials, Process Development, and Drug Delivery Strategies delves into the realm of recent advancements in pharmaceutical technology. This comprehensive book explores various common formulation strategies, encompassing the utilization of tools for statistical formulation optimization, Quality by Design (QbD), process analytical technology, and the diverse applications of pharmaceutical biomaterials, including natural polymers, synthetic polymers, modified natural polymers, bioceramics, and other bioinorganics. Furthermore, the book offers a thorough exploration of the field by providing a comprehensive understanding of pharmaceutical processes, formulation developments, explorations, and the exploitation of various pharmaceutical biomaterials to formulate pharmaceutical dosage forms.

The utilization of tools for statistical formulation optimization plays a pivotal role in enhancing the efficiency and effectiveness of pharmaceutical formulations. By employing advanced statistical techniques, researchers can optimize the composition of drugs, ensuring optimal efficacy and minimizing adverse effects. Quality by Design (QbD) is another key strategy employed in pharmaceutical development. This approach involves integrating quality considerations throughout the entire drug development process, from early stages of research to final product manufacturing. By adopting QbD principles, manufacturers can ensure the consistent quality and safety of their products, meeting regulatory requirements and patient expectations.

Process analytical technology (PAT) has emerged as a powerful tool in pharmaceutical manufacturing. PAT enables real-time monitoring and analysis of pharmaceutical processes, allowing for timely identification and resolution of process issues. This technology helps manufacturers improve process efficiency, reduce waste, and enhance product quality. Pharmaceutical biomaterials, including natural polymers, synthetic polymers, modified natural polymers, bioceramics, and other bioinorganics, have revolutionized the field of drug delivery. These materials offer unique properties such as biocompatibility, biodegradability, and controlled release, making them ideal for various drug delivery applications.

Natural polymers, such as polysaccharides and proteins, have been extensively studied for their use in drug delivery. Polysaccharides, such as cellulose and chitosan, are known for their ability to form hydrogels, which can provide sustained release of drugs. Proteins, such as albumin and gelatin, can be used to encapsulate drugs and protect them from degradation in the gastrointestinal tract. Synthetic polymers, such as polylactic acid and polyglycolic acid, have gained popularity due to their ability to mimic the properties of natural polymers and provide controlled release profiles. Modified natural polymers, such as hydroxypropyl cellulose and carboxymethyl cellulose, offer enhanced solubility and stability, making them suitable for drug delivery applications.

Bioceramics, such as calcium phosphate and titanium dioxide, have been used in drug delivery applications due to their biocompatibility and osteoconductivity. These materials can be used to form implants, coatings, and scaffolds for tissue engineering and drug delivery. Other bioinorganics, such as lipids and nucleic acids, have also shown potential in drug delivery applications. Lipids, such as liposomes and micelles, can be used to encapsulate drugs and improve their solubility and stability. Nucleic acids, such as DNA and RNA, can be used to deliver drugs specifically to target cells or tissues.

In conclusion, the field of pharmaceutical technology is constantly evolving, driven by advancements in materials, process development, and drug delivery strategies. The use of tools for statistical formulation optimization, Quality by Design, process analytical technology, and pharmaceutical biomaterials has revolutionized the way drugs are developed and manufactured. These strategies have helped improve the efficiency, safety, and effectiveness of pharmaceutical products, meeting the growing demand for personalized healthcare. However, there are still challenges to be addressed, such as developing sustainable and affordable manufacturing processes, addressing regulatory complexities, and ensuring patient access to affordable healthcare.

Weight: 910g
Dimension: 153 x 228 x 30 (mm)
ISBN-13: 9780128200438