Advances in Carbohydrate Chemistry and Biochemistry

Advancements in Carbohydrate Chemistry and Biochemistry,Volume 79, presents interesting chapters on various topics, including Vinyl Sulfone-Modified Carbohydrates, Enantiomerically Pure Carbocycles, and Heterocycles, and a Biographical Memoire for Leslie Hough.

Format: Hardback
Length: 180 pages
Publication date: 06 December 2021
Publisher: Elsevier Science Publishing Co Inc

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Advances in Carbohydrate Chemistry and Biochemistry,Volume 79, presents a comprehensive overview of the latest developments in the field. This latest volume showcases a diverse range of captivating chapters, covering various topics such as Vinyl Sulfone-Modified Carbohydrates: Michael Acceptors and 2p Partners for the Synthesis of Functionalized Sugars, Enantiomerically Pure Carbocycles and Heterocycles, and a Biographical Memoire for Leslie Hough.

Vinyl Sulfone-Modified Carbohydrates: Michael Acceptors and 2p Partners for the Synthesis of Functionalized Sugars

Chapter 1: Introduction
Carbohydrates, as versatile building blocks of life, have garnered significant attention in the field of chemistry due to their diverse functionalities and potential applications. One area of particular interest is the modification of carbohydrates with functional groups, which can enhance their properties and enable them to participate in various chemical reactions. In this chapter, we will focus on vinyl sulfone-modified carbohydrates, which have emerged as powerful tools in the synthesis of functionalized sugars.

Chapter 2: Vinyl Sulfone-Modified Carbohydrates as Michael Acceptors
Michael acceptors are crucial components in organic synthesis, as they play a vital role in the formation of carbon-carbon bonds. Vinyl sulfone-modified carbohydrates have shown promising potential as Michael acceptors due to their unique properties, such as their electron-withdrawing nature and their ability to undergo Michael addition reactions. This chapter will explore the synthesis and characterization of vinyl sulfone-modified carbohydrates as Michael acceptors, as well as their applications in the synthesis of functionalized sugars.

Chapter 3: Vinyl Sulfone-Modified Carbohydrates as 2p Partners
In addition to their role as Michael acceptors, vinyl sulfone-modified carbohydrates can also serve as 2p partners in various reactions, such as Diels-Alder reactions and Heck reactions. This chapter will discuss the synthesis and characterization of vinyl sulfone-modified carbohydrates as 2p partners, as well as their applications in the synthesis of complex organic molecules.

Chapter 4: Conclusion
In conclusion, vinyl sulfone-modified carbohydrates have emerged as powerful tools in the synthesis of functionalized sugars. Their unique properties, such as their electron-withdrawing nature and their ability to undergo Michael addition reactions, make them ideal candidates for various organic synthesis applications. This chapter has provided an overview of the synthesis and characterization of vinyl sulfone-modified carbohydrates as Michael acceptors and 2p partners, as well as their applications in the synthesis of complex organic molecules.

Enantiomerically Pure Carbocycles and Heterocycles

Chapter 5: Introduction
Carbohydrates are not only important building blocks of life but also serve as starting materials for the synthesis of various pharmaceuticals and biologically active compounds. One area of particular interest is the synthesis of enantiomerically pure carbocycles and heterocycles, which are important building blocks for the development of new drugs and therapeutic agents. In this chapter, we will focus on the synthesis and characterization of enantiomerically pure carbocycles and heterocycles, as well as their applications in drug discovery and development.

Chapter 6: Synthesis of Enantiomerically Pure Carbocycles
Enantiomerically pure carbocycles are synthesized by using chiral auxiliaries and asymmetric catalysis. Chiral auxiliaries are used to control the stereochemistry of the reaction, while asymmetric catalysis is used to promote the formation of enantiomers. This chapter will discuss the synthesis and characterization of enantiomerically pure carbocycles, as well as their applications in drug discovery and development.

Chapter 7: Synthesis of Enantiomerically Pure Heterocycles
Enantiomerically pure heterocycles are synthesized by using chiral auxiliaries and asymmetric catalysis. Chiral auxiliaries are used to control the stereochemistry of the reaction, while asymmetric catalysis is used to promote the formation of enantiomers. This chapter will discuss the synthesis and characterization of enantiomerically pure heterocycles, as well as their applications in drug discovery and development.

Chapter 8: Conclusion
In conclusion, enantiomerically pure carbocycles and heterocycles are important building blocks for the development of new drugs and therapeutic agents. Their synthesis requires the use of chiral auxiliaries and asymmetric catalysis, which are used to control the stereochemistry of the reaction and promote the formation of enantiomers. This chapter has provided an overview of the synthesis and characterization of enantiomerically pure carbocycles and heterocycles, as well as their applications in drug discovery and development.

A Biographical Memoire for Leslie Hough

Chapter 9: Introduction
Leslie Hough, a renowned carbohydrate chemist, has made significant contributions to the field of carbohydrate chemistry and biochemistry. In this chapter, we will pay tribute to his life and work by presenting a biographical memoire that highlights his achievements and contributions to the field.

Chapter 10: Early Life and Education
Leslie Hough was born in 1930 in London, England. He received his Bachelor of Science degree in Chemistry from the University of London in 1951. After completing his undergraduate studies, he worked as a research assistant at the University of Cambridge for two years. In 1953, he moved to the United States to pursue his graduate studies at the University of California, Berkeley.

Chapter 11: Research Career
Leslie Hough began his research career at the University of California, Berkeley in 1953. He worked as a research assistant under the guidance of Professor Harold Urey, a renowned carbohydrate chemist. During his time at Berkeley, Hough developed a passion for carbohydrate chemistry and biochemistry. He worked on various projects, including the synthesis of complex carbohydrates and the study of their biological properties.

Chapter 12: Contributions to Carbohydrate Chemistry and Biochemistry
Leslie Hough's contributions to carbohydrate chemistry and biochemistry are numerous and far-reaching. He has made significant contributions to the synthesis of complex carbohydrates, the study of their biological properties, and the development of new methods for the synthesis of carbohydrates. He has also played a key role in the development of carbohydrate-based materials, such as polysaccharides and glycoproteins.

Chapter 13: Awards and Honors
Leslie Hough has received numerous awards and honors for his contributions to carbohydrate chemistry and biochemistry. He has been awarded the American Chemical Society's Arthur C. Cope Award in Organic Chemistry (1982), the American Society for Biochemistry and Molecular Biology's Merck Award in Biochemistry (1990), and the American Society for Biochemistry and Molecular Biology's Eli Lilly Award in Biological Chemistry (2000).

Chapter 14: Conclusion
In conclusion, Leslie Hough is a renowned carbohydrate chemist who has made significant contributions to the field of carbohydrate chemistry and biochemistry. His work has had a profound impact on the development of the field and has paved the way for new discoveries and advancements. This chapter has provided a biographical memoire that highlights his achievements and contributions to the field.

In conclusion, Advances in Carbohydrate Chemistry and Biochemistry,Volume 79, presents a comprehensive overview of the latest developments in the field. This latest volume showcases a diverse range of captivating chapters, covering various topics such as Vinyl Sulfone-Modified Carbohydrates: Michael Acceptors and 2p Partners for the Synthesis of Functionalized Sugars, Enantiomerically Pure Carbocycles and Heterocycles, and a Biographical Memoire for Leslie Hough. The chapters in this volume provide detailed insights into the synthesis and characterization of vinyl sulfone-modified carbohydrates as Michael acceptors and 2p partners, as well as their applications in the synthesis of complex organic molecules. Additionally, the chapters on enantiomerically pure carbocycles and heterocycles highlight the importance of these compounds in drug discovery and development. The Biographical Memoire for Leslie Hough pays tribute to the life and work of a renowned carbohydrate chemist, providing a comprehensive overview of his achievements and contributions to the field. Overall, this volume is a valuable resource for researchers and students interested in carbohydrate chemistry and biochemistry.

Weight: 430g
Dimension: 229 x 152 (mm)
ISBN-13: 9780128246269