Advances in Clinical Chemistry

Advancements in Clinical Chemistry, Volume 119, covers topics such as endotoxin analysis, SARS-CoV-2 detection, osteopontin in cancer, gastrointestinal hormones, and natriuretic peptide testing strategies in heart failure.

Format: Hardback
Length: 232 pages
Publication date: 22 March 2024
Publisher: Elsevier Science Publishing Co Inc

The 119th volume of Advances in Clinical Chemistry, an esteemed series recognized globally, presents a collection of chapters authored by esteemed clinical laboratory scientists, physicians, and research scientists. This latest edition delves into diverse topics such as Advances in Endotoxin Analysis, SARS-CoV-2 Detection and Surveillance, Osteopontin in Cancer, Gastrointestinal Hormones: History, Biology, and Measurement, Natriuretic Peptide Testing Strategies in Heart Failure: a 2023 Update, and Defining Allowable Total Error Limits in the Clinical Laboratory.

These chapters offer comprehensive insights into the latest advancements and developments in clinical chemistry, encompassing a wide range of disciplines. The authors, each with extensive expertise in their respective fields, have contributed their knowledge and expertise to provide readers with a valuable resource for understanding and applying the latest techniques and methodologies in clinical practice.

Advances in Endotoxin Analysis explores the latest techniques and methodologies for the detection and analysis of endotoxins, which are important markers of inflammation and infection. The chapter discusses the use of various assays, including chromogenic, immunoassays, and nucleic acid-based methods, to accurately measure endotoxin levels in different samples. It also highlights the significance of endotoxin analysis in various clinical settings, such as intensive care units, surgical theaters, and blood banks.

SARS-CoV-2 Detection and Surveillance discusses the challenges and strategies involved in detecting and monitoring the spread of the novel coronavirus, SARS-CoV-2. The chapter explores the use of various diagnostic tests, such as reverse transcription-polymerase chain reaction (RT-PCR), antigen tests, and serological assays, to identify infected individuals and track the outbreak. It also discusses the importance of surveillance and contact tracing to prevent further spread of the virus.

Osteopontin in Cancer explores the role of osteopontin in cancer development, progression, and metastasis. The chapter discusses the expression and regulation of osteopontin in different cancer types and its association with tumor growth, angiogenesis, and immune response. It also highlights the potential of osteopontin as a biomarker and therapeutic target in cancer treatment.

Gastrointestinal Hormones: History, Biology, and Measurement discusses the history, biology, and measurement of gastrointestinal hormones. The chapter explores the role of hormones such as ghrelin, GIP, GLP-1, and PYY in regulating appetite, glucose metabolism, and gastrointestinal motility. It also discusses the techniques used to measure these hormones in different samples, including blood, urine, and stool.

Natriuretic Peptide Testing Strategies in Heart Failure: a 2023 Update discusses the use of natriuretic peptides as markers of heart failure and their role in predicting cardiovascular outcomes. The chapter explores the different natriuretic peptides, their biological functions, and the methods used to measure them in clinical practice. It also discusses the latest guidelines and recommendations for natriuretic peptide testing in heart failure management.

Defining Allowable Total Error Limits in the Clinical Laboratory discusses the importance of defining and maintaining acceptable total error limits in clinical chemistry laboratories. The chapter discusses the factors that affect total error limits, such as instrument precision, reagent quality, and operator proficiency. It also highlights the significance of quality control and quality assurance programs in ensuring accurate and reliable test results.

In conclusion, the 119th volume of Advances in Clinical Chemistry is a valuable resource for clinical laboratory scientists, physicians, and researchers. The chapters presented in this edition cover a wide range of topics and provide comprehensive insights into the latest advancements and developments in clinical chemistry. By reading this book, readers will gain a deeper understanding of the field and be able to apply the latest techniques and methodologies to improve patient care and outcomes.

Weight: 450g
Dimension: 229 x 152 (mm)
ISBN-13: 9780443295805