Advances in Medicine and Biology. Volume 188: Volume 188

This edited manuscript discusses recent advancements in medicine and biology, including the impact of lurasidone on clozapine treatment for treatment-resistant schizophrenia, intestinal protozoa diseases in immunodeficient patients, inflammasomes in neurological disorders, ion channel activation in modulating Sertoli cell behavior, sulphur-containing saponins, and Spironucleus salmonis infection on juvenile chum salmon seawater adaptability.

Format: Hardback
Length: 268 pages
Publication date: 20 October 2021
Publisher: Nova Science Publishers Inc

This edited manuscript encompasses six chapters, each delving into recent advancements in medicine and biology. Chapter One explores the impact of incorporating lurasidone into clozapine treatment for individuals with treatment-resistant schizophrenia. Chapter Two examines the prevalence and diseases associated with certain intestinal protozoa in immunocompromised patients. Chapter Three provides a comprehensive overview of inflammasomes, discussing their role in neurological disorders and exploring potential therapeutic applications. Chapter Four examines the activation of ion channels and their downstream signal transduction in regulating Sertoli cell behavior, with implications for spermatogenesis. Chapter Five offers a detailed examination of sulphur-containing saponins and their mechanisms of action. Lastly, Chapter Six assesses the pathophysiological consequences of Spironucleus salmonis infection on the seawater adaptability of juvenile chum salmon.

Chapter One:
Chapter One delves into the realm of psychopathology, specifically examining the influence of adding lurasidone to clozapine treatment for individuals with treatment-resistant schizophrenia. By combining these two medications, researchers aim to enhance the effectiveness of schizophrenia management. The chapter explores the impact of lurasidone on various aspects of psychopathology, including symptoms, cognitive functioning, and overall patient well-being. It also discusses the challenges and considerations associated with this treatment approach, such as potential side effects and drug interactions.

Chapter Two:
Chapter Two focuses on the study of intestinal protozoa and their diseases in immunocompromised patients. These protozoa can cause a range of gastrointestinal disorders, particularly in individuals with weakened immune systems. The chapter provides an overview of the different types of intestinal protozoa, their modes of infection, and the clinical manifestations associated with their infections. It also highlights the importance of proper diagnosis, treatment, and prevention strategies for these diseases.

Chapter Three:
Chapter Three explores the multifaceted role of inflammasomes in the regulation of immune responses and the development of neurological disorders. Inflammasomes are specialized immune cells that play a crucial role in the innate immune system's response to infection and inflammation. The chapter discusses the structure, function, and activation of inflammasomes and their potential therapeutic implications in neurological disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. It also explores the role of inflammasomes in the pathogenesis of autoimmune diseases and the development of neurodegenerative disorders.

Chapter Four:
Chapter Four delves into the intricate mechanisms underlying ion channel activation and downstream signal transduction in modulating Sertoli cell behavior. Sertoli cells are critical cells in the testis, responsible for supporting spermatogenesis, the process of sperm production. The chapter discusses the role of ion channels in regulating Sertoli cell function, including their involvement in calcium signaling, water balance, and hormone regulation. It also explores the downstream signaling pathways that are activated by ion channel activation and their potential impact on spermatogenesis.

Chapter Five:
Chapter Five presents a comprehensive view on sulphur-containing saponins, a group of natural compounds with diverse biological activities. Saponins are found in various plants and have been used in traditional medicine for centuries to treat various diseases. The chapter discusses the structure, properties, and biological activities of sulphur-containing saponins, including their anti-inflammatory, antioxidant, and anticancer properties. It also explores the potential therapeutic applications of sulphur-containing saponins in the treatment of cardiovascular diseases, diabetes, and other chronic diseases.

Chapter Six:
Chapter Six assesses the pathophysiological impacts of Spironucleus salmonis infection on the seawater adaptability of juvenile chum salmon. Spironucleus salmonis is a parasitic copepod that infects salmonid fish, causing significant economic losses to the aquaculture industry. The chapter discusses the life cycle diseases of Spironucleus salmonis, its modes of infection, and the physiological and molecular mechanisms by which it affects the seawater adaptability of juvenile chum salmon. It also explores the potential strategies for managing and controlling Spironucleus salmonis infection in aquaculture settings, including the use of vaccines, chemotherapy, and other biocontrol methods.

Weight: 508g
Dimension: 160 x 230 x 23 (mm)
ISBN-13: 9781685071790