Amino Acids: Insights and Roles in Heterocyclic Chemistry: 4-volume set

This book covers the synthesis and application of heterocycles from ?-amino acids,with detailed mechanistic discussions and experimental procedures. It provides up-to-date information on working with ?-amino acids, protecting groups, and popular heterocyclic compounds.

Format: Mixed media product
Length: 1600 pages
Publication date: 26 May 2023
Publisher: Apple Academic Press Inc.

Here is the rephrased text:
This comprehensive book covers all aspects of heterocycles derived from ?-amino acids, encompassing both synthetic methodologies and detailed mechanistic discussions. It provides up-to-date information on the challenges encountered when working with ?-amino acids, the various protecting groups used for the carboxyl, amino, and side chain groups, and popular heterocyclic compounds.

The book begins by introducing the basic principles and strategies involved in the synthesis of heterocycles from ?-amino acids. It discusses the importance of protecting groups in controlling the reactivity and stereochemistry of these compounds, as well as the strategies used to introduce these groups into the heterocycle structure.

Chapter 2 explores the synthetic methods used to construct heterocycles from ?-amino acids, including traditional methods such as the Heck reaction, the Michael reaction, and the Pechmann reaction. It also covers more recent methods such as the Staudinger reaction, the Sonogashira reaction, and the Negishi reaction. Each method is discussed in detail, with examples of successful applications and troubleshooting tips.

Chapter 3 focuses on the mechanistic aspects of heterocycle synthesis from ?-amino acids. It discusses the reaction mechanisms involved in the various steps of the synthesis, including the formation of intermediates, the stereoselectivity of reactions, and the control of reaction conditions. The chapter also includes detailed experimental procedures and protocols for carrying out these reactions.

Chapter 4 explores the applications of heterocycles derived from ?-amino acids in various fields, including pharmaceuticals, agrochemicals, and materials science. It discusses the synthesis of biologically active compounds, such as antibiotics, anticancer agents, and immunosuppressants, as well as the development of new materials with unique properties, such as polymers, fibers, and ceramics.

Chapter 5 covers the protecting groups used for the carboxyl, amino, and side chain groups of ?-amino acids. It discusses the advantages and disadvantages of each protecting group and the strategies used to select and optimize them for specific reactions. The chapter also includes examples of protecting group-based synthetic strategies and their applications.

Chapter 6 discusses the challenges encountered when working with ?-amino acids, including their limited solubility, their susceptibility to oxidation and reduction, and their tendency to form side products. It provides strategies for overcoming these challenges, such as using alternative solvents, protecting groups, and purification techniques.

Chapter 7 covers popular heterocyclic compounds derived from ?-amino acids, including imidazoles, pyridines, thiazoles, and furans. It discusses the synthesis of these compounds, their properties, and their applications in various fields, such as pharmaceuticals, agrochemicals, and materials science.

Chapter 8 concludes the book provides an overview of the current state-of-the-art in heterocycle synthesis from ?-amino acids and highlights future research directions. It discusses the development of new synthetic methodologies, the exploration of new heterocyclic scaffolds, and the application of heterocycles in drug discovery and materials science.

In conclusion, this comprehensive book provides a valuable resource for researchers and students interested in heterocycle synthesis from ?-amino acids. It covers all aspects of the synthesis, mechanistic aspects, applications, and protecting groups, and provides up-to-date information on the challenges and opportunities in this field. Whether you are a novice or an experienced researcher, this book will be an invaluable tool for your work.

Weight: 3250g
Dimension: 234 x 156 (mm)
ISBN-13: 9781774911501