Anhedonia: Preclinical, Translational, and Clinical Integration

Anhedonia is a key symptom of various neuropsychiatric disorders, associated with worse disease course and poor response to treatments. This handbook provides an integrative approach to anhedonia, highlighting its subcomponents and distinct neurobiological substrates. It covers history, etiology, assessments, role in disorders, reward processing subdomains, special topics, and treatments.

Format: Paperback / softback
Length: 535 pages
Publication date: 10 August 2023
Publisher: Springer International Publishing AG

Anhedonia is a significant symptom and risk factor for various neuropsychiatric disorders, including depression, schizophrenia, substance use disorders, post-traumatic stress disorders, and Parkinson's Disease, among others. Across these disorders, anhedonia has been linked to a worse disease course, including poor response to pharmacological, psychological, and neurostimulation treatments, as well as completed suicide. Recent research has revealed that anhedonia can be further divided into distinct subcomponents, including incentive motivation, consummatory pleasure, reward learning, and effort-based decision-making, each with its own neurobiological substrates. This book provides a comprehensive evaluation, synthesis, and integration of theories and empirical findings focused on anhedonia, organized across five parts. The first part covers the history, etiology, and assessments of anhedonia, while the second part explores the role of anhedonia in psychiatric and neurological disorders. Part III presents chapters that synthesize preclinical and clinical findings on different reward processing subdomains, such as reward responsiveness, reward valuation, and reward learning. Part IV focuses on selected special topics, including the transdiagnostic nature and importance of social anhedonia, the role of inflammation in the pathophysiology of anhedonia, and the use of computational modeling to "dissect" anhedonia and improve treatment outcomes. Overall, this book offers a valuable resource for researchers, clinicians, and individuals interested in understanding and addressing anhedonia and its impact on mental health.
Anhedonia, a key symptom of various neuropsychiatric disorders, including depression, schizophrenia, substance use disorders, post-traumatic stress disorders, and Parkinson's Disease, has been associated with worse disease course, poor response to treatments, and completed suicide. Recent research has revealed that anhedonia can be further divided into distinct subcomponents, including incentive motivation, consummatory pleasure, reward learning, and effort-based decision-making, each with its own neurobiological substrates. This book provides a comprehensive evaluation, synthesis, and integration of theories and empirical findings focused on anhedonia, organized across five parts. The first part covers the history, etiology, and assessments of anhedonia, while the second part explores the role of anhedonia in psychiatric and neurological disorders. Part III presents chapters that synthesize preclinical and clinical findings on different reward processing subdomains, such as reward responsiveness, reward valuation, and reward learning. Part IV focuses on selected special topics, including the transdiagnostic nature and importance of social anhedonia, the role of inflammation in the pathophysiology of anhedonia, and the use of computational modeling to "dissect" anhedonia and improve treatment outcomes. Overall, this book offers a valuable resource for researchers, clinicians, and individuals interested in understanding and addressing anhedonia and its impact on mental health.

Dimension: 235 x 155 (mm)
ISBN-13: 9783031096853
Edition number: 1st ed. 2022