Antinociceptive Tolerance to NSAIDs in Brain Limbic Areas: Role of Endogenous Opioid and Cannabinoid Systems

The development of pain as a common experience and its treatment is important, and non-steroidal anti-inflammatory drugs are the most widely used analgesics. However, prolonged use can elicit the opioid-like effect of tolerance, which can have serious adverse effects. This book provides up-to-date review information and experimental findings on antinociceptive tolerance to NSAIDs.

Format: Paperback / softback
Length: 146 pages
Publication date: 17 August 2021
Publisher: Nova Science Publishers Inc

The development of pain as a widespread phenomenon and its effective treatment holds immense significance, not only in cases where it arises from injury or inflammation, but also in chronic situations where the nerves themselves are damaged. While our understanding of pain stems from physiological studies that identify specific pain receptors or nociceptors responsible for transmitting pain sensations to the brain, the enduring nature of pain remains a complex medical and social issue. Pain relief or analgesia can be achieved through various approaches and strategies. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used analgesics, offering analgesic, antipyretic, and, at higher doses, anti-inflammatory effects. However, recent research has shed light on the potential adverse effects of prolonged NSAID use, including the development of opioid-like tolerance and the associated risk of drug withdrawal syndrome.

This book serves as a comprehensive resource, providing up-to-date review information and experimental findings related to antinociceptive tolerance to NSAIDs. The first three chapters, following the introduction, delve into literature reviews on brain limbic areas, opioid and cannabinoid systems, and non-opioid antinociceptive tolerance. Chapters Five, Six, and Seven present research data on antinociceptive tolerance to NSAIDs and the mechanisms by which opioid and cannabinoid systems attenuate nociceptive hyperalgesia in the cingulate cortex, insular cortex, and central amygdala. Chapters Eight, Nine, and Ten encompass discussions, summaries, and conclusions, along with a detailed description of experimental materials and methods.

In conclusion, the development of pain as a common experience and its treatment is a critical area of research and clinical practice. By understanding the mechanisms underlying pain, as well as the various approaches and strategies for pain relief, we can strive to improve the quality of life for individuals experiencing pain. The insights provided in this book contribute to our understanding of antinociceptive tolerance to NSAIDs and offer valuable guidance for future research and clinical interventions.

ISBN-13: 9781536198140