Apoptosis in Health and Disease - Part B

Apoptosis is a crucial process in health and disease,with new advanced understandings influencing drug discovery and the introduction of new therapies.

Format: Hardback
Length: 356 pages
Publication date: 03 June 2021
Publisher: Elsevier Science & Technology

Apoptosis, a crucial cellular process, plays a pivotal role in both health and disease. This intricate mechanism involves the regulated removal of unwanted or damaged cells, ensuring the maintenance of cellular homeostasis. In Part B, Volume 126 of the esteemed Advances in Protein Chemistry and Structural Biology series, the focus lies in exploring apoptotic responses across a wide range of conditions. From the realm of bacterial and parasite infections to pathological states such as oxidative stress, pulmonary hypertension, and various cancer types, apoptosis emerges as a central player in these diverse contexts.

Moreover, this comprehensive volume offers valuable therapeutic strategies for targeting apoptosis, presenting exciting opportunities for developing innovative treatments. These cutting-edge advancements are exerting a significant influence on drug discovery efforts, leading to the development of novel therapies that specifically aim to disrupt the cell death process.

Apoptosis, a fundamental biological process, encompasses two distinct pathways: intrinsic and extrinsic. The intrinsic pathway, triggered by internal cellular stressors, involves the activation of specific proteins and enzymes, ultimately leading to cell death. On the other hand, the extrinsic pathway is activated by external stimuli, such as tumor necrosis factor (TNF) and other cytokines, and involves the formation of apoptotic complexes that trigger cell apoptosis.

Understanding the intricacies of apoptosis is crucial in comprehending various physiological and pathological processes. It has been implicated in the development and progression of cancer, cardiovascular diseases, neurological disorders, and infectious diseases. By studying apoptosis, researchers have gained insights into the mechanisms underlying cell death, which can lead to the development of targeted therapies and improved patient outcomes.

In conclusion, apoptosis serves as a dynamic regulator of cellular health and disease. Through extensive research and therapeutic advancements, we are gaining a deeper understanding of this process, which holds the potential to revolutionize the field of medicine. By targeting apoptosis, we can develop innovative treatments for a wide range of diseases and improve the quality of life for individuals affected by these conditions.

Weight: 686g
Dimension: 162 x 238 x 25 (mm)
ISBN-13: 9780323853170