Application and Integration of Omics-powered Diagnostics in Clinical and Public Health Microbiology

Next-generation sequencing (NGS), whole genome sequencing (WGS), metagenomics, and proteomic-based methods have revolutionized molecular diagnostics, allowing for faster and more accurate identification of pathogens and the microbiome. This book covers the clinical and public health microbiology perspective, addressing the management, economic, regulatory, and operational aspects of integrating these technologies into routine diagnostics.

Format: Hardback
Length: 240 pages
Publication date: 04 June 2021
Publisher: Springer Nature Switzerland AG

The field of molecular diagnostics has undergone a remarkable transformation with the advent of various "omics" methods. Among these, next-generation sequencing (NGS) has emerged as a game-changer, enabling the rapid sequencing of a human genome in just a single day. Whole genome sequencing (WGS) has further enhanced our ability to investigate the outbreaks of numerous pathogens, providing valuable insights into their genetic makeup and evolution.

Metagenomics, another powerful "omics" tool, plays a crucial role in analyzing the complex microbiome, which aids in identifying the pathogenesis of infectious diseases. By studying the diverse array of microorganisms present in a given environment, researchers can gain a deeper understanding of how these organisms interact and contribute to disease development.

Proteomic-based methods, particularly matrix-assisted laser desorption-ionization time of flight mass spectrometry (MALDI-TOF-MS), have shown promising results in identifying myctobacteria and fungi, as well as predicting antimicrobial resistance. These techniques enable the precise identification and characterization of microbial species, providing valuable information for disease diagnosis, treatment, and prevention.

While there is a wealth of scientific publications on "omics" applications in microbiology, there are relatively few books that provide a comprehensive review of this topic from a clinical diagnostics perspective. This book aims to bridge that gap by offering a holistic approach, covering a wide range of "omics" technologies and their applications in clinical and public health microbiology. It addresses the management, economic, regulatory, and operational aspects of integrating these technologies into routine diagnostics, ensuring their effective and sustainable use.

In conclusion, the recent advancements in "omics" methods have revolutionized our understanding of microbiology and paved the way for innovative clinical diagnostics. By leveraging the power of NGS, WGS, metagenomics, and proteomics, researchers and practitioners can gain a deeper insight into the complex world of microorganisms, leading to improved disease diagnosis, treatment, and prevention. As the field continues to evolve, this book will serve as a valuable resource for practitioners and academics interested in clinical and public health microbiology.

Weight: 541g
Dimension: 235 x 155 (mm)
ISBN-13: 9783030621544
Edition number: 1st ed. 2021