Autophagy Dysfunction in Alzheimer's Disease and Dementia

Autophagy Dysfunction in Alzheimers Disease and Dementia explores the mechanisms involved in protein degradation in these diseases and the potential of drug development through autophagy modulation.

Format: Paperback / softback
Length: 356 pages
Publication date: 25 August 2022
Publisher: Elsevier Science & Technology

Autophagy Dysfunction in Alzheimer's Disease and Dementia: An Overview for Researchers and Clinicians

Autophagy, a vital cellular process, plays a crucial role in the degradation of proteins in Alzheimer's disease (AD) and dementia. In this comprehensive book, researchers and clinicians delve into the intricate mechanisms involved in protein degradation, shedding light on the implications of autophagy dysfunction in these debilitating conditions.

The book begins by exploring the role of autophagy in the clearance of damaged or misfolded proteins, which are a hallmark of AD and dementia. It highlights how autophagy dysfunction leads to the accumulation of degenerated proteins, such as aggregated tau and aggregated amyloid protein, contributing to the progression of these diseases.

Furthermore, the book delves into the potential of autophagy modulation as a therapeutic approach for AD and dementia. It discusses the development of drugs that target autophagy pathways, aiming to restore normal protein degradation and mitigate the symptoms associated with these diseases.

The book also explores the relationship between autophagy dysfunction and the accumulation of misfolded proteins that cause the death of neurons in Alzheimer's and other neurodegenerative diseases. It sheds light on the underlying mechanisms that contribute to neurodegeneration and provides insights into potential biomarkers and therapeutic targets for these conditions.

With its extensive coverage of autophagy dysfunction in Alzheimer's disease and dementia, this book serves as a valuable resource for researchers and clinicians alike. It provides a comprehensive understanding of the mechanisms involved in protein degradation and offers insights into potential drug development strategies. By unraveling the complexities of autophagy, this book contributes to the ongoing efforts to develop effective treatments for these debilitating diseases.

Weight: 586g
Dimension: 153 x 229 x 23 (mm)
ISBN-13: 9780323899062