Autophagy in Health and Disease

Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology, covering a wider range of cell types, developmental processes, and organ systems.

Format: Paperback / softback
Length: 454 pages
Publication date: 23 September 2021
Publisher: Elsevier Science Publishing Co Inc

Autophagy, a fascinating cellular process, plays a crucial role in both health and disease. In their second edition, "Autophagy in Health and Disease," renowned experts provide a comprehensive and up-to-date exploration of this intricate mechanism. This edition expands upon the scope of the first edition, covering a broader range of cell types, developmental processes, and organ systems.

The book is a collaborative effort involving investigators from 15 different countries, resulting in 28 chapters organized into six sections. The first section, Chapters 1-7, delves into foundational concepts such as the history, trajectory of research, mechanisms of autophagy, and autophagy regulation. It provides a solid foundation for understanding the basics of autophagy.

The second section, Chapters 8-11, focuses on developmental aspects, exploring stem cells, embryogenesis, hematopoiesis, and paligenosis. These chapters shed light on the role of autophagy during critical stages of human development and its potential implications for various diseases.

The subsequent sections, Chapters 12-15, delve into the role of autophagy in specific organ systems involved in metabolic control and diabetes. The authors discuss how autophagy regulates glucose metabolism, insulin sensitivity, and the development of diabetes-related complications.

Chapters 16-18 explore the cardiovascular system, highlighting the importance of autophagy in maintaining heart health and preventing cardiovascular diseases. The authors discuss how autophagy regulates blood pressure, inflammation, and the development of atherosclerosis.

Chapters 19-20 explore the nervous system, emphasizing the role of autophagy in neurodegenerative diseases, brain development, and learning and memory. The authors discuss how autophagy can protect neurons and promote cognitive function.

The final section, Chapters 21-28, addresses autophagy in other organ systems vital to human health and longevity. The authors explore the role of autophagy in the liver, kidneys, pancreas, and the immune system. They also discuss the potential for autophagy as a therapeutic target in various diseases.

In addition to these comprehensive chapters, the book includes chapters on microautophagy, chaperone-mediated autophagy, and the potential for autophagy as a therapeutic target. These chapters provide valuable insights into the intricacies of autophagy and its potential applications in medicine.

"Autophagy in Health and Disease" is an invaluable resource for anyone new to the field of autophagy as well as established investigators looking for a broader understanding of this complex mechanism. The book offers a comprehensive and up-to-date exploration of autophagy's role in health and disease, providing a solid foundation for future research and therapeutic interventions.

Weight: 1232g
Dimension: 217 x 273 x 30 (mm)
ISBN-13: 9780128220030
Edition number: 2 ed