Basic Principles of Drug Discovery and Development

The book "Basic Principles of Drug Discovery and Development" provides a comprehensive overview of the multidisciplinary process of identifying a new drug in the modern era. It emphasizes the importance of enabling technologies and a multidisciplinary team approach, and covers key topics such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine. It is designed to bridge the knowledge gaps and improve communication between scientists from different disciplines, and is suitable for students, new industrial scientists, and academics interested in drug research and development.

Format: Paperback / softback
Length: 712 pages
Publication date: 30 June 2021
Publisher: Elsevier Science Publishing Co Inc

The intricate process of discovering a novel drug in the contemporary world necessitates a collaborative effort involving a diverse team of experts, including medicinal chemists, biologists, pharmacologists, drug metabolism specialists, toxicologists, clinicians, and professionals from various other fields. The development of marketable therapeutics is significantly aided by enabling technologies such as high-throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine. Given the diverse range of disciplines and techniques involved in cutting-edge drug discovery and development, scientists must possess a deep understanding of their own field as well as a fundamental grasp of the fields of their collaborators. This book serves as a valuable resource for bridging knowledge gaps and facilitating effective communication in the early career of aspiring scientists. It provides a comprehensive understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. The fully updated text offers an excellent overview of the process, encompassing chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process.

The field of drug discovery and development is a complex and multidisciplinary endeavor that requires a collaborative effort involving a diverse team of experts. The process involves several key steps, including target identification, drug design, preclinical testing, clinical trials, and regulatory approval. Target identification involves identifying biological pathways or proteins that are involved in disease processes and developing drugs that target these pathways. Drug design involves the synthesis and optimization of potential drug candidates based on their biological activity and physicochemical properties. Preclinical testing involves testing drugs in animal models to evaluate their safety, efficacy, and pharmacokinetic properties. Clinical trials involve testing drugs in humans to evaluate their safety, efficacy, and optimal dosage. Regulatory approval involves obtaining approval from regulatory agencies such as the FDA or EMA before a drug can be marketed. The success of drug discovery and development depends on a number of factors, including scientific innovation, technological advances, and collaboration among researchers, pharmaceutical companies, and regulatory agencies. In recent years, there has been a significant increase in the use of advanced technologies such as genomics, proteomics, and high-throughput screening to accelerate drug discovery and development. These technologies allow researchers to identify potential drug targets more efficiently and to develop drugs more rapidly. However, there are also challenges associated with these technologies, such as the need for large amounts of data and the complexity of analyzing these data. Overall, drug discovery and development is a critical field that plays a vital role drug development. By leveraging advanced technologies and collaboration, researchers can continue to make progress in developing new treatments for diseases and improving the quality of life for patients around the world.

Weight: 1138g
Dimension: 152 x 229 x 40 (mm)
ISBN-13: 9780128172148
Edition number: 2 ed