Beta-Lactam Resistance in Gram-Negative Bacteria: Threats and Challenges

This book discusses antimicrobial drug resistance, specifically the resistance against the beta-lactam class of antibiotics by Gram-Negative bacteria. It explains the underlying mechanisms, genetic basis, detection methods, epidemiology, and therapeutic options. It is a valuable resource for clinical practitioners, students, and researchers in microbiology.

Format: Paperback / softback
Length: 324 pages
Publication date: 23 April 2023
Publisher: Springer Verlag, Singapore

Antimicrobial drug resistance, particularly the resistance against the beta-lactam class of antibiotics by Gram-Negative bacteria, is a pressing issue addressed in this timely publication. The book is organized into five comprehensive sections, each providing valuable insights into this complex topic.

The first section delves into the underlying mechanisms of antimicrobial resistance in Gram-negative bacteria. It explores the role of beta-lactamases, their types, classifications, inhibitors, and other factors contributing to resistance. This section offers a foundational understanding of the molecular mechanisms driving this phenomenon.

The second section delves deeper into the genetic basis of resistance. It discusses transposons, integrons, insertion sequences associated with antibiotic-resistant genes, and their role in conferring resistance. The authors provide a comprehensive overview of the genetic mechanisms underlying beta-lactam resistance, shedding light on the molecular mechanisms involved in this process.

The third section focuses on phenotypic and molecular methods to detect beta-lactam resistance. It explores various diagnostic techniques, such as antimicrobial susceptibility testing, PCR-based detection methods, and molecular assays, that are used to identify and characterize beta-lactam-resistant bacteria. These methods are crucial for timely identification and management of resistant infections.

The fourth section examines the epidemiology and prevalence of beta-lactamases in the environment. It discusses the sources, transmission routes, and environmental factors that contribute to the spread of beta-lactam-resistant bacteria. This section provides valuable insights into the environmental factors that contribute to the emergence and persistence of antimicrobial resistance.

The final section explores various therapeutic options to combat the growing public threat of antimicrobial resistance. It discusses the current reserve drugs, as well as the newer antibiotic agents that are in the pipeline. The authors provide an update on the latest developments in antibiotic therapy and highlight the importance of developing new and effective treatments to combat antimicrobial resistance.

This book is a valuable resource for clinical practitioners, students, and researchers in basic and medical microbiology. It offers a comprehensive and up-to-date overview of antimicrobial drug resistance, providing valuable insights into the mechanisms, genetic basis, detection methods, epidemiology, and therapeutic options associated with this growing public health concern. By understanding the complexities of antimicrobial resistance, healthcare professionals can better manage and prevent resistant infections, ensuring the effective use of antibiotics and preserving their effectiveness for future generations.

Weight: 534g
Dimension: 235 x 155 (mm)
ISBN-13: 9789811690990
Edition number: 1st ed. 2022