Biochemistry of Collagens, Laminins and Elastin: Structure, Function and Biomarkers

The third edition of Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides current data on key structural proteins, reviews their effects on pathologies, and discusses how modifications can alter signaling properties. It also explores the concept of cryptic signaling functions in the extracellular matrix and how this knowledge can be used to modulate chronic diseases. The book has been expanded and revised to incorporate recent research advances and emerging analytical technologies.

Format: Unspecified
Length: 584 pages
Publication date: 07 November 2023
Publisher: Elsevier Science Publishing Co Inc

The third edition of Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers offers comprehensive and up-to-date information on these crucial structural proteins. It delves into their structure, functions, and potential biomarkers, providing valuable insights into their role in various pathologies.

The book begins by exploring the fundamental aspects of collagens, laminins, and elastin, including their molecular composition, assembly, and interactions within the extracellular matrix. It discusses their involvement in tissue development, wound healing, and the regulation of cellular activities.

Furthermore, the book examines the impact of these proteins on various pathologies, such as fibrosis, cancer, and cardiovascular diseases. It highlights the mechanisms by which these proteins contribute to disease development and the potential use of biomarkers to diagnose and monitor these conditions.

One of the key highlights of this edition is the exploration of the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions with ties to endocrine function. The book discusses how this knowledge can be used to modulate various pathologies, including fibrotic disease.

To incorporate recent research advances, the book has been expanded and revised. Several new chapters explore a range of chronic diseases in which the ECM and collagens, laminin, and elastin are central players in disease modulation, including new chapters on lung, skin, and intestinal disease, as well as cancers.

Moreover, the new edition considers emerging analytical technologies that can detect biomarkers of ECM degradation, with discussion of protein quantification and detecting aging of collagens.

In conclusion, Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers, Third Edition is a valuable resource for researchers, clinicians, and students interested in understanding the biochemistry of these proteins and their role in health and disease. It provides a comprehensive and up-to-date overview of these crucial structural proteins, their structure, functions, and potential biomarkers, and their impact on various pathologies.

Weight: 1182g
Dimension: 190 x 238 x 32 (mm)
ISBN-13: 9780443156175
Edition number: 3 ed