Biomaterial Control of Therapeutic Stem Cells

Human pluripotent stem cells (hPSCs) are being used for drug discovery and regenerative medicine, but they cannot be cultured on conventional tissue culture dishes. This book provides a systematic treatment of hPSC culture on biomaterials, covering differentiation into cardiomyocytes, osteoblasts, neural lineages, and hepatocytes, and their translation into stem cell therapies for spinal cord injury, macular degeneration, bone disease, and myocardial infarction.

Format: Hardback
Length: 390 pages
Publication date: 28 February 2019
Publisher: Royal Society of Chemistry

Human pluripotent stem cells (hPSCs), encompassing both human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), hold immense promise for drug discovery and regenerative medicine applications. These remarkable stem cells, distinct from their conventional counterparts, require specialized biomaterials to support their growth and differentiation. The differentiation process is intricately regulated by the biological and physical cues provided by these biomaterials. In this comprehensive book, the author delves into the intricate aspects of hPSC culture on various biomaterial substrates. The exploration encompasses the differentiation and control of hESCs and iPSCs into diverse cell types such as cardiomyocytes, osteoblasts, neural lineages, and hepatocytes. Furthermore, the author examines the translation of these stem cell therapies into clinical trials for conditions such as spinal cord injury, macular degeneration, bone disease, and myocardial infarction. A concluding chapter on future directions provides insights into the emerging trends and advancements in the field. By utilizing this invaluable resource, readers will gain a thorough understanding of the current state-of-the-art research and a deeper comprehension of the progress made in clinical trials for stem cell therapies.

Weight: 756g
Dimension: 164 x 241 x 25 (mm)
ISBN-13: 9781788012072