BioMEMS: Biosensing Applications

This book provides an overview of the latest advances in bioMEMS for biosensing applications, including detection methods and examples. It also covers the history of BioMEMS and the design and manufacture of the first bioMEMS-based devices.

Format: Paperback / softback
Length: 178 pages
Publication date: 15 August 2021
Publisher: Springer Verlag, Singapore

This book delves into the cutting-edge advancements in bioMEMS for biosensing applications, providing a comprehensive review of diverse detection methods. These methods encompass colorimetric, fluorescence, luminescence, bioluminescence, chemiluminescence, biochemiluminescence, and electrochemiluminescence, each accompanied by examples. Moreover, the book offers an insightful overview of the historical trajectory of BioMEMS and the intricate process of designing and fabricating the initial bioMEMS-based devices.

The field of bioMEMS has witnessed remarkable progress in recent years, driven by the increasing demand for efficient and sensitive biosensing platforms. BioMEMS, which stands for biological microelectromechanical systems, combines the principles of microfabrication and biotechnology to create miniature devices capable of detecting and analyzing biological molecules.

One of the key advantages of bioMEMS is its ability to provide high-throughput detection capabilities. By integrating various detection methods into a single platform, bioMEMS can analyze large volumes of samples in a short period of time, making it ideal for applications such as point-of-care testing, environmental monitoring, and medical diagnostics.

The book explores a wide range of detection methods employed in bioMEMS, including colorimetric, fluorescence, luminescence, bioluminescence, chemiluminescence, biochemiluminescence, and electrochemiluminescence. Each method has its unique advantages and limitations, and the book provides detailed explanations of how they work and their applications in biosensing.

Colorimetric detection is one of the most commonly used methods in bioMEMS. It involves the measurement of color changes caused by the interaction of biological molecules with a sensing element, such as a dye or a protein. Colorimetric detection is highly sensitive and can be used to detect a wide range of biomolecules, including proteins, nucleic acids, and carbohydrates.

Fluorescence detection is another widely employed method in bioMEMS. It involves the excitation of biological molecules with a specific wavelength of light, which causes them to emit fluorescence. Fluorescence detection is highly specific and can be used to detect even small amounts of biomolecules.

Luminescence detection is another promising method in bioMEMS. It involves the emission of light by biological molecules in response to excitation. Luminescence detection is highly sensitive and can be used to detect a wide range of biomolecules, including proteins, nucleic acids, and carbohydrates.

Bioluminescence detection is a unique method that involves the emission of light by living organisms. It is highly sensitive and can be used to detect even small amounts of biomolecules. Bioluminescence detection is commonly used in medical diagnostics, environmental monitoring, and biological warfare.

Chemiluminescence detection is another method that involves the reaction of biological molecules with a chemical reagent to produce light. Chemiluminescence detection is highly sensitive and can be used to detect a wide range of biomolecules, including proteins, nucleic acids, and carbohydrates.

Biochemiluminescence detection is a method that involves the reaction of biological molecules with a chemical reagent to produce light. Biochemiluminescence detection is highly sensitive and can be used to detect even small amounts of biomolecules. Biochemiluminescence detection is commonly used in medical diagnostics, environmental monitoring, and biological warfare.

Electrochemiluminescence detection is a method that involves the reaction of biological molecules with an electrical current to produce light. Electrochemiluminescence detection is highly sensitive and can be used to detect even small amounts of biomolecules. Electrochemiluminescence detection is commonly used in medical diagnostics, environmental monitoring, and biological warfare.

In addition to the review of detection methods, the book also provides an overview of the history of BioMEMS and the design and manufacture of the first bioMEMS-based devices. The development of bioMEMS has been driven by the need for efficient and portable biosensing platforms that can be used in remote and underserved areas.

The first bioMEMS-based devices were developed in the early 1990s by researchers at the University of California, San Diego. These devices were designed to detect the presence of bacteria in blood samples. Since then, bioMEMS has evolved to include a wide range of applications, including drug discovery, environmental monitoring, and medical diagnostics.

The design and manufacture of bioMEMS-based devices involve a complex process that involves several steps, including microfabrication, surface modification, and integration of sensing elements. Microfabrication is the process of creating microstructures by cutting, shaping, and assembling small pieces of material, such as silicon or glass. Surface modification is the process of modifying the surface of a microstructure to enhance its properties, such as its biocompatibility or its ability to bind biomolecules.

Integration of sensing elements is the process of incorporating biological molecules or chemical reagents into a microstructure to detect their presence or activity. This can be achieved by using techniques such as microencapsulation, surface chemistry, or direct bonding.

The book also discusses the challenges and limitations of bioMEMS-based devices. One of the main challenges is the need for high-quality materials that are biocompatible and can withstand the harsh environments encountered in biosensing applications. Another challenge is the need for efficient and sensitive detection methods that can detect even small amounts of biomolecules.

Despite these challenges, bioMEMS-based devices have shown great promise in a wide range of applications. For example, they have been used to detect the presence of bacteria in blood samples, to monitor the levels of pollutants in water, and to detect the presence of cancer cells in tissue samples.

In conclusion, this book provides a comprehensive and up-to-date overview of the latest advances in bioMEMS for biosensing applications. It explores a wide range of detection methods, including colorimetric, fluorescence, luminescence, bioluminescence, chemiluminescence, biochemiluminescence, and electrochemiluminescence, and presents various bioMEMS for each. The book also offers an insightful overview of the history of BioMEMS and the design and manufacture of the first bioMEMS-based devices. As the field of bioMEMS continues to evolve, it is likely to play an increasingly important role in the development of new biosensing platforms and the improvement of healthcare and environmental monitoring.

Weight: 308g
Dimension: 235 x 155 (mm)
ISBN-13: 9789811563843
Edition number: 1st ed. 2021