Bone Cell Biomechanics, Mechanobiology and Bone Diseases

Bone Cell Biomechanics, Mechanobiology, and Bone Diseases provides a comprehensive overview of recent knowledge and advances in bone cell biomechanics and related bone diseases, highlighting the cellular basis for bone responding to mechanical stimuli. It covers osteocyte, BM-MSC, osteoblast, osteoclast, and chondrocyte cells, as well as cone diseases such as osteoporosis, scoliosis, and osteoarthritis. The book is written for researchers, scientists, clinicians, and students.

Format: Hardback
Length: 200 pages
Publication date: 01 August 2023
Publisher: Elsevier Science & Technology

Bone Cell Biomechanics, Mechanobiology, and Bone Diseases offers a comprehensive exploration of the latest advancements and insights into bone cell biomechanics and associated bone diseases, shedding light on the cellular mechanisms underlying bone's response to mechanical stimuli. This comprehensive textbook not only provides a broad overview of bone cell biology but also delves into the most recent developments in bone cell biomechanics, mechanobiology, the interplay between bone cell biomechanics and bone diseases, as well as the underlying mechanisms. By providing valuable information on the role of mechanobiology in bone health and bone diseases, as well as facilitating the investigation of novel strategies for diagnosis and therapy, this book serves as a valuable resource for researchers, scientists, clinicians, and students alike.

The book encompasses a wide range of cells involved in bone biology, including osteocytes, bone marrow-derived mesenchymal stem cells (BM-MSCs), osteoblasts, osteoclasts, and chondrocytes. It also covers various cone diseases, such as osteoporosis, scoliosis, and osteoarthritis. Written by experts in the field, this comprehensive reference is designed to cater to a diverse audience, including researchers, scientists, clinicians, and students.

The first chapter provides an introduction to bone cell biology, covering the structure, function, and development of bone cells. It discusses the cellular and molecular mechanisms that regulate bone formation, remodeling, and repair, as well as the role of bone cells in maintaining bone integrity and homeostasis. The subsequent chapters delve into the mechanics of bone, covering topics such as bone geometry, material properties, and stress and strain analysis. The authors provide detailed explanations of the principles of biomechanics, including strain and stress distribution, material properties, and finite element modeling.

Chapter 2 explores the role of mechanobiology in bone health and disease. It discusses the cellular and molecular mechanisms that regulate bone cell behavior in response to mechanical stimuli, including the effects of mechanical stress, strain, and deformation on bone cells. The chapter also highlights the importance of bone remodeling in maintaining bone strength and density and discusses the factors that contribute to bone loss, such as aging, osteoporosis, and osteoarthritis.

Chapter 3 discusses the relationship between bone cell biomechanics and bone diseases. It explores the mechanisms by which bone diseases develop, including genetic factors, environmental factors, and lifestyle factors. The chapter also discusses the diagnostic techniques used to evaluate bone diseases, such as radiography, bone densitometry, and biomechanical testing. It also provides an overview of the treatment options available for bone diseases, including medication, surgery, and physical therapy.

Chapter 4 focuses on the underlying mechanisms of bone diseases. It discusses the role of osteocytes, BM-MSCs, and other bone cells in bone remodeling and repair, as well as the factors that contribute to bone disease development. The chapter also highlights the importance of understanding the molecular mechanisms underlying bone diseases, such as osteoporosis, scoliosis, and osteoarthritis, in developing novel therapeutic strategies.

Chapter 5 explores the role of mechanobiology in bone tissue engineering. It discusses the use of stem cells, biomaterials, and growth factors to promote bone healing and regeneration. The chapter also discusses the challenges associated with bone tissue engineering, such as the development of biocompatible materials and the control of stem cell differentiation.

Chapter 6 discusses the future directions in bone cell biomechanics and mechanobiology. It discusses the emerging technologies and techniques that are being used to study bone cell behavior, such as single-cell analysis, high-throughput screening, and computational modeling. The chapter also highlights the importance of interdisciplinary research in understanding bone diseases, such as the collaboration between biologists, engineers, and clinicians.

In conclusion, Bone Cell Biomechanics, Mechanobiology, and Bone Diseases provides a comprehensive and up-to-date overview of the latest knowledge and advancements in bone cell biomechanics and related bone diseases. By covering a wide range of topics, from bone cell biology to bone diseases, and from mechanobiology to bone tissue engineering, this textbook serves as a valuable resource for researchers, scientists, clinicians, and students alike. The detailed explanations and illustrations make the content accessible and engaging, and the interdisciplinary approach encourages collaboration and innovation in the field. As our understanding of bone biology and disease continues to evolve, this textbook will undoubtedly remain a cornerstone in the study of bone health and disease.

Dimension: 229 x 152 (mm)
ISBN-13: 9780323961233