Bone Marrow Niche: Microenvironments Critical for Immune Cell Development

Recent advances in research on mesenchymal cell populations in the bone marrow are summarized in this volume, which explores how they create niches for immune cells and discusses new concepts of lympho-hematopoietic microenvironments. The book highlights the importance of mesenchymal stem cells in niches and identifies candidate cellular niches for immune cells in lymph nodes, adipose, and connective tissues.

Format: Hardback
Length: 134 pages
Publication date: 27 November 2021
Publisher: Springer Nature Switzerland AG

This comprehensive volume provides a detailed overview of recent advancements in our understanding of mesenchymal cell populations within the bone marrow. It delves into the intricate mechanisms by which mesenchymal cells establish specialized niches within extramedullary organs, thereby facilitating the localization and function of immune cells. Furthermore, the book explores emerging concepts regarding lympho-hematopoietic microenvironments, highlighting their crucial role in supporting the differentiation of hematopoietic stem cells (HSCs) into various blood cell types, including immune cells.

The book begins by introducing readers to the fundamental principles of HSC differentiation, encompassing their progression from hematopoietic stem cells to all types of blood cells, including immune cells. It emphasizes the critical role played by individual microenvironments, known as niches, in supporting and regulating this process. The identification of HSC niches has been a subject of longstanding debate, and recent studies have shed light on the crucial role of mesenchymal stem cells as the primary cellular component of these niches. The authors of this volume specifically focus on the shared features between those and HSPC niche cells in the bone marrow.

Throughout the chapters, the authors present and discuss the latest research results, providing a comprehensive and up-to-date account of the field. The book serves as a valuable resource for researchers and clinicians in hematology and immunology, offering insights into the complex interplay between mesenchymal cells, immune cells, and hematopoietic stem cell differentiation. By exploring these topics in depth, the book contributes to our understanding of the underlying mechanisms that govern immune responses and blood cell development, ultimately advancing the field of medicine.

Weight: 389g
Dimension: 235 x 155 (mm)
ISBN-13: 9783030860158
Edition number: 1st ed. 2021