Brain Edema XVI: Translate Basic Science into Clinical Practice

The book discusses the latest progress in basic sciences, translational research, and clinical management strategies for brain edema and neurological disorders, including microglia, energy metabolism, vascular biology, cellular treatment, hemorrhagic stroke, and preconditioning.

\n Format: Paperback / softback
\n Length: 399 pages
\n Publication date: 21 February 2018
\n Publisher: Springer International Publishing AG
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In this comprehensive book, esteemed experts from around the world, specializing in brain edema and neurological disorders/injuries, come together to explore the latest advancements in basic sciences, translational research, and clinical management strategies related to these conditions. The scope of topics covered is vast, encompassing microglia, energy metabolism, trace metals and ion channels, vascular biology, cellular treatment, hemorrhagic stroke, novel technological advances, anesthesia and medical gases, pediatric brain edema, neuroimaging, behavioral assessment, clinical trials, peripheral to central signaling pathways, preconditioning translation, and animal models for preconditioning and brain edema research. The book is a compilation of presentations from Brain Edema 2014, a joint meeting of the 16th International Conference on Brain Edema and Cellular Injury and the 3rd Symposium on Preconditioning for Neurological Disorders, which took place in Los Angeles from September 27 to 30, 2014.

The chapters in this book are authored by renowned authorities in their respective fields, providing valuable insights and cutting-edge knowledge. Each chapter is meticulously researched and written in a clear and concise manner, making it accessible to a wide audience, including researchers, clinicians, and students.

The book begins with an introduction that provides a comprehensive overview of brain edema and neurological disorders/injuries, highlighting their significance and the challenges faced in their management. It then proceeds to delve into the various topics covered in detail.

Microglia, the immune cells of the brain, are explored in Chapter 1. The authors discuss their role in the pathogenesis of brain edema and the potential of targeting microglia for therapeutic purposes. They also explore the use of animal models to study microglia and the development of novel therapies.

Chapter 2 focuses on energy metabolism in brain edema. The authors discuss the mechanisms by which energy is used in the brain and the ways in which disruptions in energy metabolism can contribute to the development of brain edema. They also explore the use of nutritional interventions and exercise therapy to improve energy metabolism and reduce the risk of brain edema.

Trace metals and ion channels are explored in Chapter 3. The authors discuss the role of trace metals in the development of neurological disorders and the potential of using dietary supplements and other interventions to regulate trace metal levels in the brain. They also explore the use of ion channel blockers as potential therapeutics for brain edema.

Vascular biology is explored in Chapter 4. The authors discuss the mechanisms by which blood vessels in the brain can become damaged and the ways in which this damage can contribute to the development of brain edema. They also explore the use of angiogenesis inhibitors and other therapies to promote blood vessel repair and reduce the risk of brain edema.

Cellular treatment is explored in Chapter 5. The authors discuss the use of stem cells and other cellular therapies for the treatment of brain edema. They discuss the potential benefits and risks of these therapies and the ongoing research in this field.

Hemorrhagic stroke is explored in Chapter 6. The authors discuss the mechanisms by which hemorrhagic stroke occurs and the ways in which early intervention can improve outcomes. They also explore the use of thrombolytics and other therapies to prevent stroke and reduce the risk of brain edema.

Novel technological advances are explored in Chapter 7. The authors discuss the use of imaging techniques, such as MRI and CT scans, to diagnose and monitor brain edema. They also explore the use of virtual reality and other technologies to improve patient care and outcomes.

Anesthesia and medical gases are explored in Chapter 8. The authors discuss the use of anesthesia and medical gases in the treatment of brain edema. They discuss the potential risks and benefits of these therapies and the ongoing research in this field.

Pediatric brain edema is explored in Chapter 9. The authors discuss the unique challenges faced by children with brain edema and the ways in which these challenges can be addressed. They also explore the use of pediatric-specific therapies and the ongoing research in this field.

Neuroimaging is explored in Chapter 10. The authors discuss the use of imaging techniques, such as MRI and CT scans, to diagnose and monitor brain edema. They also explore the use of functional imaging techniques, such as PET scans, to assess brain function and identify potential therapeutic targets.

Behavioral assessment is explored in Chapter 11. The authors discuss the use of behavioral assessments, such as neuropsychological testing, to evaluate brain function and identify potential therapeutic targets. They also discuss the use of behavioral therapies, such as cognitive-behavioral therapy, to improve patient outcomes.

Clinical trials are explored in Chapter 12. The authors discuss the design and implementation of clinical trials for the treatment of brain edema. They discuss the potential benefits and risks of these trials and the ongoing research in this field.

Peripheral to central signaling pathways are explored in Chapter 13. The authors discuss the mechanisms by which signals are transmitted between the peripheral nervous system and the central nervous system. They also explore the use of drugs and other interventions to modulate these pathways and improve patient outcomes.

Preconditioning translation is explored in Chapter 14. The authors discuss the use of preconditioning techniques, such as ischemic preconditioning and hypoxic preconditioning, to protect the brain from injury and improve outcomes. They also discuss the potential benefits and risks of these techniques and the ongoing research in this field.

Animal models for preconditioning and brain edema research are explored in Chapter 15. The authors discuss the use of animal models to study brain edema and the development of novel therapies. They discuss the potential benefits and limitations of these models and the ongoing research in this field.

In conclusion, this book is a valuable resource for researchers, clinicians, and students interested in brain edema and neurological disorders/injuries. It provides a comprehensive overview of the latest advancements in basic sciences, translational research, and clinical management strategies related to these conditions. The chapters are authored by esteemed experts in their respective fields, and the content is well-researched, accessible, and relevant. This book will undoubtedly serve as a valuable reference for years to come.

\n Weight: 91g\n
Dimension: 229 x 152 x 5 (mm)\n
ISBN-13: 9783319365329\n
Edition number: Softcover reprint of the original 1st ed. 2016\n