Cardiac Mechanobiology in Physiology and Disease

Cardiac mechanobiology is a field that studies the mechanics of the heart in health and disease. It covers topics such as cardiomyogenesis, cardiac remodeling, and regeneration, as well as the molecular mechanisms of mechanoperception and mechanotransduction. The book is aimed at clinicians and researchers in cardiovascular biology, bioengineering, and biophysics, and is also a valuable educational resource for young researchers and students.

Format: Hardback
Length: 353 pages
Publication date: 20 April 2023
Publisher: Springer International Publishing AG

This comprehensive book delves into the cutting-edge advancements in the field of cardiac mechanobiology, encompassing both health and disease aspects. It serves as a vital resource for clinicians and researchers alike, providing a comprehensive understanding of the mechanobiology of the heart. Cardiac mechanobiology encompasses a wide range of topics, including cardiomyogenesis, cardiac remodeling, and regeneration. It also delves into the molecular mechanisms of mechanoperception and mechanotransduction in cardiomyocytes, shedding light on how these cells respond to mechanical stimuli. Furthermore, the book explores the intriguing field of stretch-induced differentiation of cardiomyocytes derived from induced pluripotent stem cells, offering potential insights into heart repair and regeneration.

This volume, part of the esteemed series "Cardiac and Vascular Biology," complements the previously published volume "Vascular Mechanobiology in Physiology and Disease" (volume 8). It is meticulously designed to cater to a diverse audience, including cardiovascular biology, bioengineering, and biophysics professionals, as well as aspiring young researchers and students in these fields.

The book is organized into chapters that cover various aspects of cardiac mechanobiology. Each chapter is authored by experts in the field, ensuring a thorough and up-to-date exploration of the subject matter. The chapters are well-structured, with clear headings, subheadings, and illustrative figures to enhance understanding and clarity.

The first chapter provides an introduction to cardiac mechanobiology, defining its scope and highlighting the importance of understanding the mechanical aspects of the heart in both normal and pathological conditions. It also provides an overview of the key concepts and principles that underpin the study of cardiac mechanobiology.

The subsequent chapters delve into specific aspects of cardiac mechanobiology. Chapter 2 explores cardiomyogenesis, the process by which the heart develops from precursor cells. It discusses the molecular mechanisms involved in cardiomyocyte differentiation, as well as the role of mechanical forces in shaping the heart's structure and function. Chapter 3 focuses on cardiac remodeling, a response to various stressors that can lead to heart disease. It discusses the mechanisms by which cardiac cells respond to stress, including changes in gene expression, protein synthesis, and cell signaling. Chapter 4 delves into the field of cardiac regeneration, which involves the repair and restoration of damaged heart tissue. It explores the cellular and molecular mechanisms involved in cardiac regeneration, as well as the potential applications of these mechanisms in the treatment of heart disease.

In addition to these chapters, the book also includes a comprehensive review of the molecular mechanisms of mechanoperception and mechanotransduction in cardiomyocytes. It discusses the sensors and transducers that detect and respond to mechanical stimuli, as well as the signaling pathways that mediate these responses. The book also explores the role of mechanical forces in regulating cardiomyocyte function, including the regulation of heart rate, contractility, and relaxation.

Furthermore, the book discusses the application of cardiac mechanobiology in clinical settings. It explores the use of mechanical stimulation techniques, such as cardiac pacing and magnetic resonance imaging-guided cardiac stress testing, to diagnose and treat heart disease. It also discusses the role of mechanical forces in the development of cardiovascular diseases, such as atherosclerosis and heart failure.

In conclusion, this book is a valuable resource for clinicians, researchers, and students in the field of cardiovascular biology, bioengineering, and biophysics. It provides a comprehensive and up-to-date exploration of the latest findings in cardiac mechanobiology, covering a wide range of topics from cardiomyogenesis to cardiac regeneration. The book is well-written, accessible, and illustrated, making it an ideal educational tool for both novice and experienced researchers. By leveraging the knowledge and insights presented in this book, clinicians and researchers can better understand the mechanisms underlying heart disease and develop innovative therapies to improve patient outcomes.

Weight: 711g
Dimension: 235 x 155 (mm)
ISBN-13: 9783031239649
Edition number: 1st ed. 2023