Characterization of Odorant Patterns by Comprehensive Two-Dimensional Gas Chromatography

The book focuses on multidimensional gas chromatography (heart-cutting systems, comprehensive 2D-GC systems, and hybrid solutions) and its applications in investigating complex odor-active volatiles. Contributions from experts cover fundamentals, sensomics, platforms, and mass spectrometry. Real-world examples include food volatiles, complex aroma mixtures, and forensic and medical applications.

Format: Hardback
Length: 442 pages
Publication date: 18 February 2022
Publisher: Elsevier - Health Sciences Division

The volume delves into the realm of multidimensional gas chromatography (heart-cutting systems, comprehensive 2D-GC systems, and hybrid solutions) as its primary focus, with a keen emphasis on its distinctive features for in-depth exploration of complex fractions of odor-active volatiles. Contributions from esteemed researchers hailing from both academia and industry span a wide range of fundamental aspects related to olfaction, including the physiology of smell, strategies for identifying key odorants from the vast array of detectable volatiles (sensomics), the principles of operation of multidimensional analytical platforms (such as comprehensive two-dimensional gas chromatography – GC×GC, heart-cut 2D-GC, hybrid systems), and the indispensable role of mass spectrometry in delivering reliable and informative data. Furthermore, insights into new system designs and configurations are offered, encompassing sample preparation and data processing strategies, which are crucial steps in the entire analytical process. Real-world examples encompass a diverse array of volatiles, including food volatiles, complex aroma mixtures, odors emitted from industrial plants, and volatiles of interest in forensic and medical applications.

Introduction:
Multidimensional gas chromatography (heart-cutting systems, comprehensive 2D-GC systems, and hybrid solutions) has emerged as a powerful tool in the field of odor analysis, enabling the comprehensive investigation of complex odor-active volatiles. This volume brings together contributions from renowned researchers across academia and industry, showcasing their expertise in this area. By exploring the fundamentals of olfaction, the identification of key odorants, the operation of multidimensional analytical platforms, and the role of mass spectrometry, the book provides valuable insights into the realm of odor analysis.

Physiology of Olfaction:
The first chapter delves into the physiological aspects of olfaction, shedding light on the mechanisms by which humans and other organisms perceive and interpret odors. The authors discuss the sensory cells involved in odor perception, the neural pathways that transmit odor signals, and the molecular mechanisms that underpin odorant recognition. This chapter serves as a foundation for understanding the complexities of odor perception and the challenges associated with analyzing odor-active volatiles.

Strategies for Identifying Key Odorants:
The second chapter focuses on the strategies employed to identify key odorants from the vast array of detectable volatiles. The authors explore various sensomics techniques, such as gas chromatography-mass spectrometry (GC-MS), solid-phase microextraction (SPME), and odorant identification libraries, which are used to isolate and identify specific odorants from complex mixtures. These techniques enable the identification of odorants that play a significant role in the overall odor profile of a substance, facilitating the development of odor-based identification systems.

Principles of Operation of Multidimensional Analytical Platforms:
The third chapter delves into the principles of operation of multidimensional analytical platforms, including comprehensive two-dimensional gas chromatography (GC×GC) and heart-cut 2D-GC. The authors explain how these platforms enable the separation and analysis of odor-active volatiles in a single experiment, providing a more efficient and comprehensive approach to odor analysis. They discuss the advantages of these platforms, such as increased resolution, increased selectivity, and the ability to analyze a broader range of odor-active volatiles.

Mass Spectrometry in Providing Reliable and Informative Data:
The fourth chapter highlights the indispensable role of mass spectrometry in odor analysis. The authors discuss the various mass spectrometry techniques, such as gas chromatography-mass spectrometry (GC-MS), ion mobility spectrometry (IMS), and tandem mass spectrometry (MS/MS), which are used to identify and characterize odor-active volatiles. They discuss the advantages of mass spectrometry, such as high sensitivity, specificity, and the ability to provide detailed information about the chemical composition of odor-active volatiles.

New Systems Design and Configurations:
The fifth chapter explores new systems design and configurations for odor analysis. The authors discuss the development of specialized sample preparation techniques, such as solid-phase microextraction (SPME) and microfluidics, which are used to enhance the extraction and analysis of odor-active volatiles from different sample types. They also discuss the use of advanced data processing strategies, such as pattern recognition and machine learning, to analyze and interpret odor data more effectively.

Real-World Examples:
The final chapter provides real-world examples of odor analysis in various industries. The authors discuss the analysis of food volatiles, complex aroma mixtures, odors emitted from industrial plants, and volatiles of interest in forensic and medical applications. These examples showcase the practical applications of multidimensional gas chromatography and the insights gained from analyzing odor-active volatiles in different contexts.

Conclusion:
In conclusion, this volume offers a comprehensive and up-to-date overview of multidimensional gas chromatography and its applications in odor analysis. The contributions from esteemed researchers provide valuable insights into the fundamentals of olfaction, the identification of key odorants, the operation of multidimensional analytical platforms, and the role of mass spectrometry. The real-world examples showcase the practical applications of these techniques in different industries, highlighting the importance of odor analysis in various fields. By exploring the complexities of odor perception and the challenges associated with analyzing odor-active volatiles, this book serves as a valuable resource for researchers, scientists, and practitioners in the field of odor analysis.

Weight: 1000g
Dimension: 229 x 152 (mm)
ISBN-13: 9780323988810