Charnolophagy in Health and Disease: With Special Reference to Nanotheranostics

Charnolophagy (CP) is an energy-driven, lysosomal-dependent mitochondrial inclusion-specific pleomorphic Charnoly body (CB) autophagy (ATG) involving free radical-induced Ca2+ dyshomeostasis, ΔΨ collapse, and ATP depletion in congenital diseases, pressure ulcers, metabolic diseases, hepatic diseases, diabetes, obesity, inflammatory diseases, musculoskeletal diseases, sarcopenia, cachexia, respiratory diseases, gastrointestinal diseases, hyperlipidemia, skin and hair diseases, pulmonary diseases, cardiovascular diseases, renal diseases, sepsis-induced multi-organ failure, reproductive diseases, inflammatory diseases, ophthalmic diseases, neurodegenerative diseases, drug addiction, aging, microbial (including COVID-19) infections, and belligerent malignancies. This book introduces personalized theranostic charnolopharmacotherapeutics to cure them, including DRESS and GELS principles, nanoparticles, antioxidants, CB antagonists, CP regulators, and CS stabilizers.

Format: Paperback / softback
Length: 586 pages
Publication date: 25 September 2023
Publisher: Taylor & Francis Ltd

This comprehensive book delves into the fascinating realm of charnolophagy (CP), a unique form of mitochondrial inclusion-specific pleomorphic Charnoly body (CB) autophagy (ATG) driven by energy. It explores the underlying mechanisms behind this process, including the involvement of free radicals, Ca2+ dyshomeostasis, ΔΨ collapse, and ATP depletion, which are prevalent in various congenital diseases, pressure ulcers, metabolic disorders, hepatic diseases, diabetes, obesity, inflammatory diseases, musculoskeletal diseases, sarcopenia, cachexia, respiratory diseases, gastrointestinal diseases, hyperlipidemia, skin and hair diseases, pulmonary diseases, cardiovascular diseases, renal diseases, sepsis-induced multi-organ failure, reproductive diseases, inflammatory diseases, ophthalmic diseases, neurodegenerative diseases, drug addiction, aging, microbial (including COVID-19) infections, and belligerent malignancies.

The book presents a comprehensive approach to understanding and treating these conditions through evidence-based personalized theranostic charnolopharmacotherapeutics. It discusses the principles of basic DRESS and GELS, nanoparticles for curing chronic multidrug-resistant (MDR) diseases, antioxidants as free radical scavengers, CB antagonists, CP regulators, and CS stabilizers for mitigating CB molecular pathogenesis (CBMP). Additionally, specific guidelines are provided for environmental protection and preservation of zoological and botanical species at the verge of extinction, the Triple I Hypothesis for mitochondrial quality control, and the transcriptional regulation of CSexR and CSendoR for curing chronic diseases.

Furthermore, a novel CP index is introduced to evaluate MDR malignancies and other chronic diseases. This index utilizes various parameters to assess the severity and progression of these conditions, providing valuable insights for healthcare professionals and researchers. The book is a valuable resource for a wide range of stakeholders, including WHO, CDC, FDA, NIH, policy planners, cosmetologists, trichologists, players, athletes, dancers, wrestlers, equestrians, young women, the aging population, toxicologists, environmental protectionists, pharmaceutical professionals, and researchers.

By unraveling the complexities of charnolophagy and presenting effective therapeutic strategies, this book aims to improve the quality of life and longevity for individuals affected by these debilitating conditions. It underscores the importance of personalized medicine and the need for targeted interventions to address the diverse range of diseases implicated in early morbidity and mortality.

Weight: 453g
Dimension: 254 x 178 (mm)
ISBN-13: 9780367679866