Chemical Biology of the Genome

Chemical Biology of the Genome provides a comprehensive overview of genomic and epigenomics dynamics through the lens of chemical biology,with an emphasis on physiological and pathophysiological processes and drug discovery.

Format: Paperback / softback
Length: 350 pages
Publication date: 05 February 2021
Publisher: Elsevier Science Publishing Co Inc

The field of chemical biology of the genome offers a comprehensive exploration of the dynamic aspects of genomic and epigenomic processes, drawing upon the principles of chemical biology. Through the lens of this discipline, essential concepts and principles are illuminated, showcasing the significance of chemical biology in studying and analyzing the genome and epigenome.

To illustrate the practical applications of chemical biology in genomic and epigenomic research, numerous examples and case studies are provided. These examples emphasize the relevance of chemical biology to physiological and pathophysiological processes, as well as drug discovery. Authored by esteemed experts in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, the book adopts an integrated and interdisciplinary approach, emphasizing the increasing utilization of rapid evolving chemical and mass-scale sequencing tools in interpreting biochemical processes of the genome.

Subsequent sections delve into the realm of chemical modifications of the genome, DNA sequence recognition by proteins, gene regulation mechanisms, genome-wide association studies (GWAS) and epigenome-wide association studies (EpiGWAS), the three-dimensional architecture of the genome, and the functional genome architecture. In-depth chapters are dedicated to exploring interventions in gene networks through techniques such as small interfering RNA (siRNA)/short hairpin RNA (shRNA), microRNA (miRNA), and anti-miR, as well as the modulation of induced pluripotent stem cells (iPS) using small molecules. Additionally, the book explores drug resistance pathways altered by DNA methylation as potential drug targets, the therapeutic potential of anti-miRs, and the use of nanodelivery systems for drug delivery.

By presenting a comprehensive and multidisciplinary perspective, this text serves as a valuable resource for researchers, students, and practitioners in the fields of chemical biology, genomics, epigenomics, and related disciplines. It provides a deep understanding of the molecular mechanisms underlying genomic and epigenomic processes, enabling the development of new strategies for disease diagnosis, treatment, and drug discovery.

Dimension: 235 x 191 (mm)
ISBN-13: 9780128176443