Cholesterol: From Chemistry and Biophysics to the Clinic

Drs. Anna Bukiya and Alex Dopico have compiled a comprehensive resource on biological and clinical aspects of cholesterol,spanning biophysics and biochemistry,as well as the latest pharmacological discoveries employed to tackle disorders associated with abnormal cholesterol levels.

Format: Paperback / softback
Length: 1058 pages
Publication date: 01 May 2022
Publisher: Elsevier Science & Technology

Drs. Anna Bukiya and Alex Dopico have authored a comprehensive resource on the biological and clinical aspects of cholesterol, encompassing biophysics and biochemistry, as well as the latest pharmacological discoveries employed to tackle disorders associated with abnormal cholesterol levels. The early chapters provide guidance in cholesterol lab chemistry, cholesterol metabolism and synthesis, molecular evolution of cholesterol and sterols, cholesterol peptides, and cholesterol modulation. The subsequent chapters delve into cellular and organismal development, discussing cholesterol transport in blood, lipoproteins, and cholesterol metabolism; cholesterol detection in the blood; cellular cholesterol levels; hypercholesterolemia; and the role of cholesterol in early human development. Pathophysical specialists explore familial hypobetalipoproteinemia, critical illness and cholesterol levels, coronary artery disease, CESD, cholesterol and viral pathology, cholesterol and neurodegenerative disorders, and cholesterol and substance use disorders. A concluding section examines the pharmacology of drug delivery systems targeting cholesterol-related disorders, cholesterol receptors, cholesterol reduction, statins, citrate lyase, cyclodextrins, and clinical management. Cholesterol: From Biophysics and Biochemistry to Pathology and Pharmacology empowers researchers, students, and clinicians across various disciplines to advance new cholesterol-based studies, improve clinical management, and drive drug discovery.

Dimension: 235 x 191 (mm)
ISBN-13: 9780323858571