Chromatin And Epigenetics: An Introduction To Epigenetic Mechanisms

Epigenetics is a controversial term that denotes the mechanisms that instruct the genome on how to express the purely genetic information that encodes proteins. Advances in epigenetics in the past 15 years have revealed how it lies at the heart of virtually every branch of biological and medical sciences. This book is an introduction to epigenetics and is designed to help train a new generation of biologists and health scientists.

Format: Hardback
Length: 524 pages
Publication date: 31 July 2023
Publisher: World Scientific Publishing Co Pte Ltd

Epigenetics is a complex and contentious field that delves into the mechanisms that govern how the genome expresses the genetic information that encodes proteins. Its origins can be traced back to the discovery of repressor proteins in the 1960s, evolving into a comprehensive guide for the genetic information. Over the past 15 years, significant advancements in epigenetics have shed light on its profound implications across various biological and medical disciplines. Consequently, a fundamental grasp of its core principles is crucial for every student engaged in this field.

The field of chromatin and epigenetics has witnessed remarkable growth in the past 15 to 20 years. Initially, the pace of epigenetic research was rapid, driven by continuous discoveries and breakthroughs. However, as the basic mechanisms and implications of epigenetics became more established, the field has entered a phase of consolidation and consensus. Researchers have reached a shared understanding of these processes and their implications, which has seamlessly integrated into our understanding of the genome.

Genes are not merely DNA sequences; they encompass a wide range of biological functions and regulatory mechanisms. This realization has revolutionized our understanding of the genome, gene expression, and its regulation in development, health, and disease. Epigenetics plays a pivotal role.

The present book emerged from a course taught at Rutgers University for the past 13 years to advanced undergraduates. It has been designed to provide a comprehensive and engaging introduction to epigenetics, encompassing its historical background, theoretical foundations, and practical applications. The book is extensively illustrated, offering a wealth of specific examples and case studies to facilitate a deeper understanding of the subject matter. Additionally, a chapter dedicated to methods and techniques has been included, highlighting the key approaches that have driven the advancements in epigenetics research.

In conclusion, epigenetics is a rapidly evolving field that holds immense significance in understanding the complexity of biological processes. This book serves as a valuable resource for students, researchers, and practitioners alike, offering a comprehensive and up-to-date account of epigenetic mechanisms, their implications, and their applications in various fields. As our understanding of epigenetics continues to expand, it will undoubtedly shape our future endeavors in biology, medicine, and other related disciplines.

ISBN-13: 9789811257629