Chromatin Remodeling Complexes and Transcriptional Coregulators

Chromatin Remodeling Complexes and Transcriptional Coregulators,Volume 53,covers new advances in the field,including Perspectives on Chromatin Remodeling,ISWI-type Remodelers in Yeast,Conserved Mechanisms of NuRD Function,SIN3 Complex as a Metabolic Epigenetic Regulator,Soft Repression and Chromatin Modification,NPAC-LSD2 Complex in Nucleosome Demethylation,Role of Intrinsically Disordered Domains in Transcriptional Regulation,and Regulation of Cancer Recovery from Therapy Exposure by Noncoding RNAs.

Format: Hardback
Length: 208 pages
Publication date: 01 October 2023
Publisher: Elsevier Science Publishing Co Inc

Chromatin Remodeling Complexes and Transcriptional Coregulators,Volume 53,the latest release in The Enzymes series, highlights new advances in the field, with interesting new chapters that cover Perspectives on Chromatin Remodeling, The functions of ISWI-type remodelers in yeast, Conserved mechanisms of NuRD function in hematopoietic gene expression, The SIN3 complex as a metabolic epigenetic regulator, Soft repression and chromatin modification by conserved transcriptional corepressors, The NPAC-LSD2 complex in nucleosome demethylation, Role of intrinsically disordered domains in transcriptional regulation, and Regulation of the Recovery of Cancer from Therapy Exposure by Noncoding RNAs.

Chromatin remodeling complexes and transcriptional coregulators play crucial roles in regulating gene expression and maintaining the integrity of the genome. In recent years, significant progress has been made in understanding the mechanisms and functions of these complexes.

One area of focus has been on perspectives on chromatin remodeling. This chapter provides an overview of the different types of chromatin remodeling complexes and their roles in regulating gene expression. It also discusses the emerging concepts and challenges in the field.

Another important chapter is on the functions of ISWI-type remodelers in yeast. ISWI-type remodelers are a family of proteins that play a critical role in chromatin remodeling and gene expression regulation. This chapter explores the mechanisms by which ISWI-type remodelers function and their role in various cellular processes, such as DNA repair, replication, and transcription.

Conserved mechanisms of NuRD function in hematopoietic gene expression is another fascinating chapter. NuRD is a chromatin remodeling complex that plays a crucial role in regulating gene expression in hematopoietic cells. This chapter discusses the conserved mechanisms by which NuRD functions and its role in hematopoietic differentiation and development.

The SIN3 complex as a metabolic epigenetic regulator is another important chapter. The SIN3 complex is involved in the regulation of metabolic pathways and gene expression. This chapter explores the mechanisms by which the SIN3 complex functions and its role in regulating metabolic homeostasis.

Soft repression and chromatin modification by conserved transcriptional corepressors is another interesting chapter. Corepressors are proteins that repress gene expression by binding to specific DNA sequences and preventing the transcriptional machinery from accessing the promoter region. This chapter discusses the mechanisms by which corepressors function and their role in regulating gene expression.

The NPAC-LSD2 complex in nucleosome demethylation is another important chapter. Nucleosome demethylation is a process that involves the removal of methylation marks on histone proteins, which can regulate gene expression. This chapter discusses the mechanisms by which the NPAC-LSD2 complex functions and its role in nucleosome demethylation.

Role of intrinsically disordered domains in transcriptional regulation is another fascinating chapter. Intrinsically disordered domains are regions of proteins that lack a defined structure and are often involved in protein-protein interactions. This chapter discusses the mechanisms by which intrinsically disordered domains function and their role in regulating gene expression.

Regulation of the Recovery of Cancer from Therapy Exposure by Noncoding RNAs is another important chapter. Noncoding RNAs, such as microRNAs and long noncoding RNAs, play a crucial role in regulating gene expression and cellular processes. This chapter discusses the mechanisms by which noncoding RNAs regulate cancer recovery and their potential as therapeutic targets.

Overall, Chromatin Remodeling Complexes and Transcriptional Coregulators, Volume 53, provides a comprehensive and up-to-date overview of the latest advances in the field of chromatin remodeling and transcriptional coregulation. The chapters are written by experts in the field and cover a wide range of topics, making it an essential resource for researchers and students interested in this area.

Weight: 450g
Dimension: 229 x 152 (mm)
ISBN-13: 9780443160073