Shulph Ink
Cytochrome P450: In Vitro Methods and Protocols
Cytochrome P450: In Vitro Methods and Protocols
YOU SAVE £14.17
- Condition: Brand new
- UK Delivery times: Usually arrives within 2 - 3 working days
- UK Shipping: Fee starts at £2.39. Subject to product weight & dimension
Couldn't load pickup availability
Excellent- More about Cytochrome P450: In Vitro Methods and Protocols
This collection provides detailed experimental protocols for setting up in vitro cytochrome P450 assays, which are essential for selecting drug candidates in a drug discovery pipeline. It covers factors affecting drug metabolism, such as CYP expression levels, kinetic parameters, inhibition, induction, stability, UGT stability, excretion mechanisms, and drug-drug interactions. Written for the Methods in Pharmacology and Toxicology series, the book offers a step-by-step protocol, common and unexpected experimental problems, and references for further reading.
Format: Paperback / softback
Length: 379 pages
Publication date: 10 July 2022
Publisher: Springer-Verlag New York Inc.
This comprehensive collection delves into intricate experimental protocols essential for establishing diverse in vitro cytochrome P450 (CYP) assays, which play a pivotal role in the selection of drug candidates within a drug discovery pipeline. The intricate interplay of factors influencing drug metabolism, encompassing CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), is extensively addressed in this volume. Written with the esteemed Methods in Pharmacology and Toxicology series in mind, the chapters provide valuable background information on the in vitro assay, a comprehensive list of all the necessary materials, reagents, and equipment, a step-by-step protocol, informative notes containing common and unexpected experimental challenges encountered during the assay, as well as comprehensive references for further supplementary reading. Authored by esteemed experts in the field, Cytochrome P450: In Vitro Methods and Protocols emerges as an indispensable guide for researchers engaged in the exploration and development of novel medicinal compounds.
Weight: 743g
Dimension: 254 x 178 (mm)
ISBN-13: 9781071615447
Edition number: 1st ed. 2021
This item can be found in:
UK and International shipping information
UK and International shipping information
UK Delivery and returns information:
- Delivery within 2 - 3 days when ordering in the UK.
- Shipping fee for UK customers from £2.39. Fully tracked shipping service available.
- Returns policy: Return within 30 days of receipt for full refund.
International deliveries:
Shulph Ink now ships to Australia, Belgium, Canada, France, Germany, Ireland, Italy, India, Luxembourg Saudi Arabia, Singapore, Spain, Netherlands, New Zealand, United Arab Emirates, United States of America.
- Delivery times: within 5 - 10 days for international orders.
- Shipping fee: charges vary for overseas orders. Only tracked services are available for most international orders. Some countries have untracked shipping options.
- Customs charges: If ordering to addresses outside the United Kingdom, you may or may not incur additional customs and duties fees during local delivery.
