Cytogenomics

Cytogenomics is essential for understanding the human genome, and new high-throughput approaches are necessary to advance cytogenetics in the 21st century. This book discusses the strengths and advantages of cytogenomic research methods and technologies, such as banding, molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping, and CRISPR-cas9 applications. It also demonstrates recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure, multilayer organization of chromosomes, role of repetitive elements and noncoding RNAs, studies in topologically associated domains, interchromosomal interactions, and chromoanagenesis.

Format: Paperback / softback
Length: 428 pages
Publication date: 27 May 2021
Publisher: Elsevier Science Publishing Co Inc

Cytogenomics is a groundbreaking field that plays a pivotal role in understanding the human genome. By employing advanced high-throughput approaches, cytogenetics is poised to make significant advancements in the 21st century. This comprehensive book provides a comprehensive introduction to (molecular) cytogenetics, serving as the foundation for all cytogenomic research. It highlights the strengths and unique advantages of cytogenomic research methods and technologies, empowering researchers to embark on their projects and effectively gather and interpret chromosomal data.

The book delves into various methods, including banding and molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping, and CRISPR-cas9 applications for cytogenomics. The second half of the book showcases recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure across different tissue types, gaining insights into the multilayer organization of chromosomes, exploring the role of repetitive elements and noncoding RNAs in the human genome, examining topologically associated domains, studying interchromosomal interactions, and delving into chromoanagenesis.

This book serves as an invaluable reference source for researchers, students, basic and translational scientists, clinicians, genetic counselors, clinical laboratory geneticists, bioethicists, and fertility specialists. It encompasses a wide range of topics relevant to human genetics, genomics, reproductive medicine, gynecology, obstetrics, internal medicine, oncology, bioinformatics, medical genetics, and prenatal testing. By unraveling the complexities of the human genome through cytogenomics, this book empowers researchers to make groundbreaking discoveries and contribute to the betterment of human health and well-being.

Weight: 890g
Dimension: 235 x 191 (mm)
ISBN-13: 9780128235799