γδ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation provides an overview of the current clinical and preclinical γδ T cell immunotherapy landscape, addressing challenges, proposing solutions, and mapping next steps. It covers γδ T cell biology, combination trials, therapeutic persistence, cytotoxic effector function, functional exhaustion, and cytokine addiction mitigation, and allograft persistence-enhancement techniques. It is valuable for translational specialists, academic scientists, commercial scientists, and clinicians.

Format: Hardback
Length: 208 pages
Publication date: 01 November 2024
Publisher: Elsevier Science Publishing Co Inc

γδ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation

γδ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation sets out and critically discusses the current clinical and relevant preclinical γδ T cell immunotherapy landscape. In five chapters, field experts discuss the challenges facing γδ T cell oncoimmunotherapy, propose solutions, and map next steps. Particular attention is given to summarizing our understanding of the complex, translationally relevant human γδ T cell biology, the evidence basis for designing γδ T cell combination trials and data-driven perspectives on what is known—and what isn't—about γδ T cell therapeutic persistence. Various perspectives are provided on how issues of cytotoxic effector function, functional exhaustion, and cytokine addiction can be mitigated using gene engineering. A chapter is dedicated to the systematic review of all γδ T cell immunotherapy trials to date, and the cell therapy products that were used in these trials. The final chapter discusses allograft persistence-enhancement techniques in the context of γδ T cell therapy, covering lymphodepleting chemotherapy and synthetic stealth engineering.

γδ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation

γδ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation gives an updated and comprehensive insight into the current state of γδT cell immunotherapy, which is of interest to existing translational γδ T cell specialists, the proliferating range of academic scientists and commercial scientists entering the field, as well as clinicians who may encounter γδ T cell immunotherapy in the clinic, or are wishing to familiarize themselves with noncanonical lymphocyte immunotherapy.

Weight: 450g
Dimension: 235 x 191 (mm)
ISBN-13: 9780443217661