Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183, is a collection of selected studies on intrinsically disordered proteins, covering evolution, phase separation, functions, characterization, molecular simulations, and more.

Format: Hardback
Length: 434 pages
Publication date: 19 October 2021
Publisher: Elsevier Science & Technology

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183, is a comprehensive collection of selected studies exploring diverse research topics related to intrinsically disordered proteins. This volume delves into various aspects, including the evolution of disorder, the peculiarities of phase separation in the prion protein, a comprehensive examination of the interplay between intrinsic disorder and protein functions, detailed structural and functional characterization of several significant intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane-associated proteins with ID regions, discussions on molecular simulations of IDPs, and much more.

The evolution of disorder is a central theme in this volume, as researchers investigate the mechanisms and factors that contribute to the formation of disordered structures in proteins. They explore the historical trends and evolutionary pressures that have shaped the prevalence and characteristics of disorder in different protein families. The peculiarities of phase separation in the prion protein are also examined in detail. Prion proteins are notorious for their ability to self-propagate and cause severe neurological disorders, such as Creutzfeldt-Jakob disease. Researchers analyze the structural and chemical properties of prion proteins that enable their phase separation behavior and explore the implications of this behavior for disease pathogenesis.

The relationships between intrinsic disorder and protein functions are another key focus of this volume. Researchers investigate how intrinsic disorder can affect protein stability, folding, and interactions with other proteins and molecules. They explore the potential roles of disorder in protein function, such as regulating protein activity, facilitating protein-protein interactions, and contributing to protein misfolding and aggregation. The structural and functional characterization of several important intrinsically disordered proteins is also covered in depth. Transcription factors, outer membrane porins, trans-membrane and membrane-associated proteins with ID regions, are among the proteins that play critical roles in various biological processes. Researchers employ various experimental techniques, such as X-ray crystallography, NMR spectroscopy, and molecular dynamics simulations, to unravel the structures, dynamics, and functions of these proteins.

Molecular simulations of intrinsically disordered proteins are another important topic explored in this volume. These simulations provide valuable insights into the behavior and dynamics of these proteins, which are challenging to study experimentally. Researchers employ advanced computational methods to simulate the folding, stability, and interactions of IDPs, shedding light on their structural and functional properties.

Furthermore, this volume includes discussions on the clinical significance of intrinsically disordered proteins. Researchers explore the role of these proteins in various diseases, such as cancer, neurodegenerative disorders, and infectious diseases. They discuss the potential therapeutic implications of targeting intrinsically disordered proteins and the challenges associated with developing effective therapies.

In conclusion, Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183, is a valuable resource for researchers and scholars interested in intrinsically disordered proteins. This volume provides a comprehensive overview of the current state of knowledge in this field, covering topics such as evolution, disorder, phase separation, protein functions, structural characterization, molecular simulations, and clinical significance. The selected studies presented in this volume contribute to our understanding of the complex nature of intrinsically disordered proteins and their potential implications for various biological processes and diseases.

Weight: 450g
Dimension: 229 x 152 (mm)
ISBN-13: 9780323852999