Design and Analysis of Pragmatic Trials

This book provides a comprehensive guide to pragmatic cluster randomized trials (PCTs) and sample size calculations. It discusses the advantages and disadvantages of various PCTs,and offers sample size formulas and sensitivity analyses to address pragmatic issues. The generalized estimating equation (GEE) method is employed to derive sample size formulas for different types of outcomes. Various experimental designs are covered,and the book demonstrates how the GEE approach can accommodate hierarchical correlation structures and random cluster sizes. It is useful for practitioners and biostatistics students involved in clinical trial design.

Format: Hardback
Length: 206 pages
Publication date: 16 May 2023
Publisher: Taylor & Francis Ltd

Analyses,and examples for sample size calculation.

Employ the generalized estimating equation (GEE) method to derive sample size formulas for various types of outcomes from the exponential family,including continuous,binary,and count variables.

Explore experimental designs that have been frequently employed in PCTs,such as cluster randomized designs,matched-pair cluster randomized design,stratified cluster randomized design,stepped-wedge cluster randomized design,longitudinal cluster randomized design,and crossover cluster randomized design.

Demonstrate that the GEE approach is flexible to accommodate pragmatic issues such as hierarchical correlation structures,different missing data patterns,randomly varying cluster sizes,etc.

Investigate the remedy for this limitation in the design of PCTs.

Provide practitioners with a description of the advantages and disadvantages of various PCTs and sample size formulas that address various pragmatic issues,facilitating the proper implementation of PCTs to improve health care.

Serve as a textbook for biostatistics students at the graduate level to enhance their knowledge or skill in clinical trial design.

Weight: 438g
Dimension: 162 x 242 x 18 (mm)
ISBN-13: 9780367627355