DNA Origami: Structures, Technology, and Applicati ons

DNA origami is a technique that uses single-stranded DNA template molecules to assemble target two- and three-dimensional shapes at the nanoscale. It has applications in drug delivery systems, circuitry in plasmonic devices, and biological detection, diagnosis, and therapeutics. This book provides a comprehensive guide for newcomers and discusses interdisciplinary studies in various fields.

Format: Hardback
Length: 464 pages
Publication date: 10 May 2022
Publisher: John Wiley and Sons Ltd

Discover the fascinating world of DNA origami, a cutting-edge subfield of DNA nanotechnology that has the power to shape and transform our understanding of biology and materials science. DNA origami is the art of assembling single-stranded DNA template molecules into precise two- and three-dimensional shapes at the nanoscale. This incredible technique involves annealing templates with hundreds of DNA strands and then binding them together through complementary base pairing. The unique properties of DNA molecules, such as molecular recognition, self-assembly, programmability, and structural predictability, have opened up a wide range of intriguing applications.

In this comprehensive book, DNA Origami, renowned experts from various fields come together to explore the current state and future prospects of this rapidly evolving field. The book begins by delving into the intricate world of structural design and assembly systems, providing a deep understanding of how DNA origami can be used to create complex structures and devices. It then goes on to discuss interdisciplinary studies, highlighting the ways in which DNA origami is being applied in chemistry, materials science, physics, biophysics, biology, and medicine.

One of the key applications of DNA origami is in the creation of new functional materials. By combining the principles of chemistry and materials science, researchers can design and engineer DNA origami structures that possess specific properties and functionalities. For example, DNA origami can be used to create biomaterials with tailored properties, such as self-assembly, responsiveness to external stimuli, or drug delivery capabilities.

Another exciting area of research is in single-molecule analysis and measurements. DNA origami offers a powerful platform for studying the behavior and interactions of individual molecules, which is crucial in fields such as physics and biophysics. By folding DNA into specific shapes, researchers can create sensors, detectors, and even molecular machines that can detect and manipulate small molecules with high precision.

In the realm of biological detection, diagnosis, and therapeutics, DNA origami holds immense potential. By designing DNA origami structures that mimic the structures of biomolecules, researchers can create sensors and probes that can detect and identify specific diseases or pathogens. These structures can also be used as drug delivery vehicles, allowing drugs to be targeted to specific cells or tissues with greater efficiency.

Furthermore, DNA origami is being used to study the behavior of biological systems at the molecular level. By folding DNA into complex structures, researchers can simulate the behavior of proteins, enzymes, and other biological molecules, providing insights into their function and interactions. This has the potential to lead to the development of new drugs and therapies for a wide range of diseases.

In addition to its scientific applications, DNA origami has also found its way into various fields such as electronics, architecture, and art. For example, DNA origami structures can be used to create flexible displays, wearable devices, and even architectural structures. The unique properties of DNA origami, such as its ability to fold and unfold, make it a versatile material for creating innovative and visually stunning designs.

Overall, DNA origami is a rapidly evolving field with immense potential to revolutionize our understanding of biology and materials science. This book provides a comprehensive guide for newcomers, covering both fundamental and developmental aspects of DNA origami technology. With contributions by a leading team of experts, DNA Origami offers expert views from different angles, making it an essential resource for anyone interested in this exciting field.

Weight: 946g
Dimension: 270 x 184 x 28 (mm)
ISBN-13: 9781119682547