Drug Delivery to the Brain: Physiological Concepts, Methodologies and Approaches

The development of new CNS drugs is difficult due to the blood–brain barrier (BBB). Factors such as active/passive transport, intra-brain distribution, and central/systemic pharmacokinetics are critical for CNS drug delivery. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiological considerations.

Format: Hardback
Length: 806 pages
Publication date: 25 May 2022
Publisher: Springer Nature Switzerland AG

The development of novel central nervous system (CNS) drugs poses significant challenges due to the intricate nature of the brain and the formidable barriers it presents. These barriers, including the blood-brain barrier (BBB), pose a formidable challenge to drug delivery. To overcome these challenges, several critical factors must be considered, such as active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics.

Neurological diseases and trauma conditions further complicate CNS drug delivery by altering the dynamic nature of CNS barriers, drug distribution, and pharmacokinetics. A comprehensive understanding of these factors and their intricate interplay is essential for successful CNS drug development and disease treatment.

In recent years, substantial progress has been made in unraveling the complexities of CNS drug delivery. Researchers have gained valuable insights into the many factors that influence drug action within the brain. This book aims to provide a comprehensive overview of small and large drug delivery to the brain, with a particular emphasis on the physiology of the BBB and the principles and concepts for drug delivery across this barrier.

The book encompasses various methods and approaches for studying drug delivery, including in vitro and in vivo techniques, as well as computational simulations. It discusses the various routes and methods of drug administration into the brain, considering the influence of disease on drug delivery and distribution. Additionally, the book provides insights from the drug industry perspectives and includes a primer on neuroanatomy and physiological considerations tailored specifically for drug delivery scientists.

By presenting cutting-edge research and educational content, this book aims to serve as a valuable resource for academic and industry scientists seeking to advance their knowledge in CNS drug delivery. It provides comprehensive references to original publications, enabling readers to delve deeper into the subject matter and stay up-to-date with the latest developments in the field.

In conclusion, the development of novel CNS drugs is a complex and challenging endeavor that requires a thorough understanding of the many factors that influence drug action within the brain. This book serves as a valuable resource for researchers, clinicians, and drug delivery scientists, providing a comprehensive overview of small and large drug delivery to the brain, with a particular emphasis on the physiology of the BBB and the principles and concepts for drug delivery across this barrier. By presenting cutting-edge research and educational content, this book aims to contribute to an in-depth understanding of the interplay.

Weight: 1400g
Dimension: 235 x 155 (mm)
ISBN-13: 9783030887728
Edition number: 2nd ed. 2022