Emerging Concepts in Ribosome Structure, Biogenesis, and Function

Ribosome biogenesis is the process of making ribosomes responsible for mRNA translation into proteins. It is a tightly regulated process linked to cell division, growth, and development. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides an overview of the ribosome factory, structure, and function, and its potential in translational research.

Format: Paperback / softback
Length: 296 pages
Publication date: 30 September 2021
Publisher: Elsevier Science Publishing Co Inc

Ribosome biogenesis is a complex and intricate process that plays a vital role in the translation of mRNA into proteins. It is a tightly regulated process that is intricately linked to nearly all biochemical and cellular processes, including cell division, growth, and development. Understanding the mechanisms of ribosome biogenesis is crucial for comprehending how cells function and respond to various stimuli.

The ribosome factory, the cellular organelle responsible for ribosome biogenesis, is a highly specialized structure. It consists of several large and small ribosomal subunits, each playing a specific role in the translation process. The ribosomal RNA (rRNA) is responsible for binding amino acids and forming the ribosome's peptidyl transferase center, while the ribosomal proteins (rPs) are involved in various stages of protein synthesis, such as mRNA binding, chain initiation, and elongation.

Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a comprehensive and synthesized overview of all the components involved in ribosome biogenesis. The book begins by introducing the ribosome factory and its evolution, including its origin and the mechanisms that have contributed to its development. It then delves into the structure of the ribosome, including the subunits, RNA, and protein components.

The book also discusses the emerging concepts in ribosome research, such as the emergence of ribosomopathies, which are genetic disorders that affect ribosome biogenesis. It explores how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes that have specific functions that may translate differentially with consequences on normal and pathological processes.

In addition, the book provides fundamental coverage and emerging research on ribosomes, biogenesis, and their structure and function. It is a resourceful introduction for new researchers and those engaged in interdisciplinary ribosomal research.

Overall, ribosome biogenesis is a critical process that is essential for the proper functioning of cells. By understanding the mechanisms of ribosome biogenesis, researchers can gain insights into various diseases and develop new therapeutic strategies to improve human health.

Weight: 450g
Dimension: 229 x 152 (mm)
ISBN-13: 9780128163641